New trial to help healthy women avoid unnecessary breast operations, UK

[News]

Researchers at the University of Birmingham and University Hospitals Birmingham NHS Trust are launching a breast screening study aimed at improving the treatment of ductal carcinoma in situ (DCIS) by only operating on women who need surgery - rather than all of those who show signs of abnormal cells.

More...

['lizbeth]

Wow, as a cancer survivor I can't fathom leaving DCIS in the body and just monitoring it. Yikes! Even low-risk DCIS.

But getting 1000 women to participate is mind boggling. From my reading Aussiegirl's post and online the biopsy sample is like a crap shoot. It's like a box of chocolates - you never know what your are going to get! It is just a sample and not the entire lesion - which may be heterogeneous.

I read in the NCCN guidelines after DCIS surgeries they find Invasive Ductal Carcinoma in 25% of the specimens.

Maybe it is just me but I'm just cringing at this study.

I see LORIS is a poster at SABCS, along with another study that Sarah & I would find interesting. I posted below. The conference starts today. I hope we learn some interesting and helpful information from it.

['lizbeth]

OngoingClinical Trials 2: DCIS OT2-3-01 The LORIS trial: A multicentre, randomized phase III trial of standard surgery versus active monitoring in women with newly diagnosed low risk ductal carcinoma in situ
Francis A, Bartlett JMS, Billingham LJ, Bowden SJ, Brookes CL, Dodwell DJ, Evans AZ, Fallowfield LJ, Gaunt CH, Hanby AM, Jenkins VA, Pinder S, Reed MW, Roberts T, Thomas JS, Wallis MG, Wilcox MH, Rea DW. Queen Elizabeth Hospital, Birmingham, United Kingdom; University of Birmingham, Birmingham, United Kingdom; Ontario Institute for Cancer Research, Toronto, ON, Canada; University of Dundee, Dundee, United Kingdom; University of Sussex, Brighton, United Kingdom; University of Leeds, Leeds, United Kingdom; King's College London, London, United Kingdom; University of Sheffield, Sheffield, United Kingdom; Western General Hospital, Edinburgh, United Kingdom; Addenbrooke's Hospital, Cambridge, United Kingdom; Independent Cancer Patients' Voice, England, United Kingdom; St. James's Hospital, Leeds, United Kingdom.


OT2-3-02
NSABP B-43: A phase III clinical trial to compare trastuzumab (T) given concurrently with radiation therapy (RT) to RT alone for women with HER2+ DCIS resected by lumpectomy (Lx)
Cobleigh MA, Anderson SJ, Juilan TB, Siziopikou KP, Arthur DW, Rabinovitch RA, Zheng P, Mamounas EP, Wolmark N. National Surgical Adjuvant Breast and Bowel Project (NSABP); Rush University; University of Pittsburgh Graduate School of Public Health; Allegheny Cancer Center at Allegheny General Hospital; Northwestern University Feinberg School of Medicine; Virginia Commonwealth University; University of Colorado Denver; MD Anderson Cancer Center, Orlando.

[SusanN]

Hey there Mister Sister!! That is CRAZY...I really trust my BS...LOOK at my signature...until I had my mastectomy...FINAL PATHOLOGY...YIKES IS RIGHT!!!!

I should edit my "signature"...I was High Grade DCIS...

['lizbeth]

Hello Mister Sister.

High risk DCIS with a surprise, eh? IDC.

You've finished all your chemo? Now you can enjoy the holidays without all the lovely side effects!

[SusanN]

I'm coming to the end...so happy...next Tuesday I'll have an Infusion, then the end of March or first of April, I'll be done!!

My hair is SLOWLY coming back...UGHHH...just don't feel like "stylin' & profylin'" a SHORT pixie right now...too cold in Nebraska!! Haha!!