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Old 08-12-2008, 07:41 AM   #1
rebecca0623
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Path report results

After my quadrantectomy on 7.30.08 just got path results. All 3 nodes taken are clear but there is lymphatic/vascular invasion and we are doing the BRCA testing. I wil lhavd chemo and radiation but it is a good day for me!!! Thanks for all the support! Off to find a wig...
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Dx June 2008, Age 44
Mother Dx age 54, deceased
1.2 cm tumor right breast, grade 3, ER 4+; PR 3+
HER2 +, invasive ductal carcinoma
Quadrantectomy right on 7/30/08
Path report, all 3 nodes taken were clear!!!!!!
Lymphatic/vascular invasion and sent out BRCA testing
Port in on 9/2/08. Chemo began 9/3/08. TCH (MUGA wrong - echocardiogram says 65% cardiac MRI 59% 9/10/98 elevated liver enzymes, PET scan 9/16/08 all clear.
TC ended 12/17/08
Port blood clot and hosp. 1/2/09
radiation begins 1/8/09


BRCA testing done - results NEGATIVE!

cardiologist said go back to coreg as it helps counteract heart effects of herceptin and slowly increase dosage - now 40mg daily.
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Old 08-12-2008, 12:30 PM   #2
Joan M
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Rebecca, Glad to hear that your nodes are clear. That's a start in the right direction. Best, Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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Old 08-12-2008, 01:21 PM   #3
Brenda_D
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I'm glad to hear you had good news.

If I may ask, how do they know there's lymphatic/vascular invasion?
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Old 08-12-2008, 01:32 PM   #4
rebecca0623
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Good question. I had a "how to read your path report" booklet from the American Cancer Society and they sent me to a class prior to surgery. One of the items you are told to look for in path report was "lymphatic/vascular invasion" in tumor. This is not the same as lymph node involvment but it is another marker of an aggressive tumor. I found mine clearly spelled out on path report and surgeon told me as well.
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Dx June 2008, Age 44
Mother Dx age 54, deceased
1.2 cm tumor right breast, grade 3, ER 4+; PR 3+
HER2 +, invasive ductal carcinoma
Quadrantectomy right on 7/30/08
Path report, all 3 nodes taken were clear!!!!!!
Lymphatic/vascular invasion and sent out BRCA testing
Port in on 9/2/08. Chemo began 9/3/08. TCH (MUGA wrong - echocardiogram says 65% cardiac MRI 59% 9/10/98 elevated liver enzymes, PET scan 9/16/08 all clear.
TC ended 12/17/08
Port blood clot and hosp. 1/2/09
radiation begins 1/8/09


BRCA testing done - results NEGATIVE!

cardiologist said go back to coreg as it helps counteract heart effects of herceptin and slowly increase dosage - now 40mg daily.
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Old 08-12-2008, 01:56 PM   #5
Lien
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My onc explained to me at the time, that they check the excised lymphatic and blood vessels for stray cancer cells. If none are present, the cells are still contained within the tumor. If some are present, but none are in the lymph nodes, they haven't gone very far, and you got the tumor out just in time. It does mean that this type of cancer is able to spread, so it's probably a good idea to have chemo and rads. That way, any remaining stray cells can be eradicated.

Lien
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Diagnosed age 44, January 2004, 0.7 cm IDC & DCIS. Stage 1, grade 3, ER/PR pos. HER2 pos. clear margins, no nodes. SNB. 35 rads. On Zoladex and Armidex since Dec. 2004. Stopped Zoladex/Arimidex sept 2009 Still taking mistletoe shots (CAM therapy) Doing fine.
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Old 08-12-2008, 03:51 PM   #6
Brenda_D
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I pulled out my path report and it doesn't mention anything about lymphatic/vascular invasion.
The only way I knew I had a positive inner mammary node, was from the Pet/ct scan, and they showed it to me on both the Pet and the CT.
I was just curious since you had negative axillary nodes too.
Like I said, congrats on that. Every little bit of good news helps.
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12/12/06- IDC Stage III, 4x A/C, 35 rads, Herceptin 1 year
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Old 08-13-2008, 03:44 AM   #7
CoachPlayWin
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I, too, had lymphovascular invasion with no nodal involvement. There isn't a lot of attention paid to this, but I worry about the implications. Does this often lead to metastasis? They always seem to zero in on the lymph nodes as the avenue.
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dx 07/20/07 with IDC
left MRM with expander 08/07
2.2 cm er/pr-, her2+ all nodes clear
2/08 BRCA negative
4 AC dose dense 09/06/07-10/18/07
12 weekly Taxol/Herceptin 11/01/07-01/18/08
Herceptin 1 year/done 10/31/08!
2/08 reconstuction
port out 12/4/08
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Old 08-13-2008, 04:45 AM   #8
Lien
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I think the nodes are more important for deciding about therapy. The vascular invasion just tells them that the cancer was ready to start spreading. But as there was nothing in the lymph nodes, it probably hasn't spread yet through the lymphatic system.

These days, most surgeons do a sentinel node biopsy. Before the surgery, a marker is injected into the tumor, to see where the lymphatic fluid goes. During surgery the first node (or nodes) where the marker showed up are removed and sent to pathology. That way the surgeon knows which lymph nodes could be affected. They don't need to remove all nodes, and if lymphatic fluids go to other nodes besides those in your armpit, they are more easily detected. I think this procedure has a 95% success rate, meaning that it finds 95% of all affected nodes.

Hope this helps.

Lien
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Diagnosed age 44, January 2004, 0.7 cm IDC & DCIS. Stage 1, grade 3, ER/PR pos. HER2 pos. clear margins, no nodes. SNB. 35 rads. On Zoladex and Armidex since Dec. 2004. Stopped Zoladex/Arimidex sept 2009 Still taking mistletoe shots (CAM therapy) Doing fine.
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Old 08-13-2008, 04:57 AM   #9
KathyH
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thoughts and prayers

Hi Friend,
I'm glad your nodes were clear. We don't live that far from each other. I just talked to someone here in my city who is newly diagnosed as of yesterday. I'm sad that so many are affected by this disease but am so grateful that such strides have been made in curing this disease. Take care.
Blessings, Kathy H
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Kathy H
Diagnosed July 05 age 39
right side - stage 3c grade 3 occult BC, her2++, er/pr -
left side - likely stage 1 her2 -, er/pr+
4 A/C
Nov 05 - complete clinical remission
4 Taxotere/Herceptin
Surgery Feb 06 - pathologic complete remission
9 months of Herceptin
36 rad on right
Tamoxifen - 5yrs
NED!
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Old 08-13-2008, 06:22 AM   #10
mts
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Cancer cells are big and can hardly fit through the tiny vascular structures... Picture a cherry trying to get through a straw...
BUT- since cancer is so unpredictable, the chemo and rads are necessary to catch the strays.

Maria
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