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Old 09-09-2020, 09:44 AM   #1
Nguyen
Senior Member
 
Join Date: Nov 2005
Posts: 274
Latest Overview of the Cyclin-Dependent Kinases 4/6 Inhibitors...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856891/

Don’t remember if I posted this before, can’t believe I am hogging this section (articles of interest), please feel free to tell me to stop. Anyway, whenever the word “latest” or similar appears in the article’s title, be sure to check at least the publication date.

“…Studies have reported that ESR1 mutation with ongoing trial's confirmation (NCT02738866) and loss of ER, upregulation of fibroblast growth factor receptor (FGFR) amplification, and acquired RB1 mutations 46 were in correlation with acquired CDK4/6 inhibitors resistance….”

Can the above be the reason for “rapid progression” after CDK4/6 treatment?

Nguyen
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