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Old 10-02-2014, 08:38 PM   #1
Senior Member
Join Date: Dec 2005
Posts: 148
Does TDM1 cross blood brain barrier

Did anyone of you have TDM1 with metastasis to brain lung liver and bones.
How were the results and how many cycles did it take to get a good result.
Please please reply as tdm1 seems to be my last weapon and we will have to pay a lot from our pocket
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Old 10-03-2014, 06:29 AM   #2
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Join Date: Jul 2008
Posts: 186
Re: Does TDM1 cross blood brain barrier

Recently reported abstract at ESMO re: possible t-dm1 activity in her2+ brain metastases.

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Old 10-11-2016, 01:02 AM   #3
Join Date: Aug 2016
Posts: 5
Re: Does TDM1 cross blood brain barrier

No, TDM1 is a large molecule that does NOT cross the BBB. Thus another technique is needed to prevent brain mets. I recently shifted from Herceptin to TDM1 as a result of what might (not certain) have been early signs of progression. While on Herceptin I was also using Tykerb (lapatinib) which DOES cross the BBB, especially with a pulsed dosing regimen. However Tykerb appears to be incompatible with TDM1 so I'm looking for an alternative. See post of my history and experimental treatment with Tykerb here.
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