Brain mets, WBRT, SRS, TDM1 and a VP shunt

[Chuck18]

Not sure if this is the right forum. If not, please let me know which one to post in.
My wife received TDM1 for the first time on March 9th, and had a severe reaction, with greatly increased brain edema. We found out later that this was also discovered at the University of Colorado in patients that had undergone previous SRS, as reported in the Feb 2014 Neuro-Oncology journal. My wife has also undergone three rounds of SRS in 2013.
After initial treatment with high steroid dosages, the oncologist, neurosurgeon & radiation oncologist decided to insert a VP shunt, which has helped.*My wife is now scheduled to restart the TDM1 today,, and also undergo another round of SRS in about 2 months. The doctors here admit that they do not know of any similar cases that include brain mets, WBRT, SRS, TDM1 and a VP shunt. They called my wife a "pioneer".
Is there anyone out there who is aware of a similar scenario?