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Old 02-24-2010, 05:08 PM   #1
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Join Date: Feb 2010
Posts: 2
herceptin after chemo??

I finished my chemo on 1-13-10 (act) and am having radiation now, when my oncologist calls me and tells me they retested my pathology results and found i am HER2+. They do not know yet what the best course of treatment should be, just herceptin or starting another round of taxol w/the herceptin. Has anyone received herceptin without being on chemo??
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Old 02-24-2010, 05:44 PM   #2
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Posts: 823
Re: herceptin after chemo??

I started my Herceptin after I finished my Chemo. I started it about a week after I finished Chemo, and also had my Rad's at the same time. This was back in 2005 for me.
Biopsy Dx'd 3-23-05 Age 48
MRM 4-5-05 w/ 2 tumor's 5cm, and 6 cm (right side)
IDC (poorly differentiated infiltrating ductual carcinoma)
5+/16 nodes
Stage III A
Grade 3
ER/PR-, Her2/neu ++
Ki67 78%
Begin Chemo 5-2-05 4XAC Dose Dense , 4X Abraxane Dose Dense (ended August 05)
28 Rad's ended October 13 2005
Started Herceptin Weekly August 2005 for one year
Had a Simple mastectomy left side after Mamo showed incresed micro-calcifications. Jan. 17 2006.
Brain MRI Feb.2006--All Clear
August 28, 2006 Last Weekly Herceptin.
October 2006--Colonoscopy, 6 Polyp's removed--all B9
PET Scan July 2007
Abdominal MRI Oct. 2007---2 Right Kidney Cysts
Core Biopsy-- Lump on Scar Line 1-10-08---B9
Brain MRI 6-2008--All Clear
PET/CT Scan 6-2008
Sept. 8 2008, 4CM area removed from mastectomy scar line. Proved to be B9.
PET/CT Scan-- July 2009 --All clear
August 17,2009 ---Had Port Removed
6 Years NED -- April 5,2011
DX'd with Melanoma left arm 10-10-2011
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Old 02-24-2010, 06:42 PM   #3
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Re: herceptin after chemo??

Why did they choose to treat you with herceptin alone, without chemo? Isn't it suppose to be more beneficial when given with chemo? I am just confused since it took them so long to get me the proper diagnosis, I just want the best treatment option.
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Old 02-24-2010, 11:13 PM   #4
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Location: Cordoba, Mexico
Posts: 672
Re: herceptin after chemo??


I also got my Herceptin after chemo and radiation. My onc tried to give me chemo and Herceptin at the same time, but I could not stand them together, I had to much vomit when this happened. I got one year Herceptin after I had fineshed radiation and could stand it pretty well with almost no side-effects.
Dx. June 30th, 2006 at age 43
Lumpectomy rt breast
2.2 cm tumor, 13 nodes all negative
32 Rads
Dx. Lung fibrosis due to radiation
Ended 1 year herceptin in March, 2008
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Old 02-25-2010, 12:50 AM   #5
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Re: herceptin after chemo??

I received Herceptin two weeks after I finished AC & T chemo.

Karen W
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Old 02-25-2010, 05:38 AM   #6
Pam P
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Location: MN
Posts: 731
Re: herceptin after chemo??

You don't mention your status. If you are stage IV and there are areas of known cancer still I would think herceptin and chemo. If you are stage III or less, then herceptin alone as a precaution/preventative agent I think is commonly done.
6/01 IBC er+ her2+stage IIIb; mastecomy
7/01 AC, taxol; radiation
2/02 tamoxifen
9/02 stage IV bone mets femara
1/03 taxotere/herceptin/aredia
6/03 herceptin, aredia & faslodex
1/04 navelbine, herceptin, aredia
2/05 herceptin/aredia
7/05 xeloda/herceptin/aredia
3/07 xeloda/tykerb/aredia
5/08 taxol/avastin/aredia
2/09 gemzar/herceptin/zometa
7/09 Taxol/Carbo/Herceptin, zometa
10/09 navelbine/herceptin & zometa
2/10 herceptin & tykerb & zometa
4/10 add xeloda &aromasin
10/10 dx with dermatomyiositis triggered by cancer
11/10 restart herceptin, tykerb, zometa
12/10 surgery-place rod in R femur to stabilize bone
1/11 radiation to R femur - 20 tx
2/11 2nd surgery - rod in Left femur
2/11 tx eribulen -- suspended dx brain mets
3/11 brain mets wbr 20 tx
4/11 halaven; discontine 8/11 not working
8/11 radiation to left femur 20 tx'
8-9/11 rad to lower spine
9/11 abraxane/herceptin/zometa
9/12 xeloda/herceptin/zometa
12/12 ablation of liver
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Old 02-25-2010, 02:02 PM   #7
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Location: Stockton, NJ
Posts: 4,172
Re: herceptin after chemo??

I also had the Herceptin after chemo. The 2009 SABCS presentation says that Herceptin still works great after chemo but works better with chemo. However, if you have early bc and finished chemo already, I am not sure if you would have to do more Taxol as the benefit is already there.
Kind regards


Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 16 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 03-04-2010, 03:40 AM   #8
Christine MH-UK
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Posts: 414
Re: herceptin after chemo??

Yes, I have received it, but that was a while ago and the trend seems to be towards herceptin with chemo.

As far as I know, there was only one trial that compared herceptin after chemo with herceptin with chemo. Trial N9831 suggests that herceptin after chemo definitely improves disease-free survival (return of disease goes down by about 1/3). Herceptin with chemo though is considered to be even better since it reduces recurrence by another 1/4.

Here is the info on the trial, N9831:

If any Her2-wonks are interested, here are some slides from Dr. Perez:
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