HonCode

Go Back   HER2 Support Group Forums > her2group
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 03-23-2011, 08:16 PM   #1
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,776
pH Balanced Gel for atrophic vaginitis in bc survivors

apparently just getting the pH right without the estrogen improves symptoms

Obstet Gynecol. 2011 Apr;117(4):922-7.
Vaginal pH-Balanced Gel for the Control of Atrophic Vaginitis Among Breast Cancer Survivors: A Randomized Controlled Trial.
Lee YK, Chung HH, Kim JW, Park NH, Song YS, Kang SB.

From the Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
Abstract
OBJECTIVE: : To estimate the effects of vaginal pH-balanced gel on vaginal symptoms and atrophy in breast cancer survivors treated with chemotherapy or endocrine therapy.

METHODS: : This was a randomized, double-blind, placebo-controlled study. Breast cancer survivors who experienced menopause after chemotherapy or endocrine therapy were voluntarily enrolled and randomly administered vaginal topical pH-balanced gel or placebo three times per week for 12 weeks. Vaginal dryness and dyspareunia were measured by visual analog scale, vaginal health index, and vaginal pH. The endometrium and ovary were evaluated by transvaginal ultrasonography.

RESULTS: : Among 98 enrolled women, 86 completed the treatment (n=44 and n=42 for the pH-balanced gel group and placebo group, respectively). Vaginal dryness and dyspareunia improved more in the pH-balanced gel group than in the placebo group (baseline mean 8.20 compared with end-point mean 4.23 [P=.001] and 8.23 compared with 5.48 [P=.040], respectively). Vaginal pH-balanced gel reduced the vaginal pH (gel: baseline mean 6.49 compared with end-point mean 5.00; placebo: 6.22 compared with 5.69 [P<.001]), and enhanced vaginal maturation index (gel: 45.5 compared with 51.2; placebo: 46.4 compared with 47.9 [P<.001]) and vaginal health index (gel: 15.8 compared with 21.1; placebo 14.3 compared with 16.98 [P=.002]). There was no significant difference in adverse effects between the two groups except for mild irritation at the early time of pH-balanced gel administration.

CONCLUSION: : Vaginal pH-balanced gel could relieve vaginal symptoms and improve vaginal health in breast cancer survivors who have experienced menopause after cancer treatment.

CLINICAL TRIAL REGISTRATION: : ClinicalTrials.gov, www.clinicaltrials.gov, NCT00607295.

LEVEL OF EVIDENCE: : I.

PMID: 21422866
Lani is offline   Reply With Quote
Old 03-23-2011, 09:23 PM   #2
caya
Senior Member
 
caya's Avatar
 
Join Date: Jan 2007
Location: Thornhill, Ontario Canada
Posts: 2,318
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

Lani,

Any idea where we can get this gel - what is it called, is it a prescription etc.?

Thanks for any additional information.

all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08

Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
14 Years NED!!
caya is offline   Reply With Quote
Old 03-24-2011, 02:28 AM   #3
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,776
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

the article was out of Korea but it cites a clinical trial number which you ought to be able to look up @ clinical trials.gov

They should have an investigator and/or a primary corresponding author

In the meantime, I will see if I can get the full article and get back to you if I obtain some answers
Lani is offline   Reply With Quote
Old 03-24-2011, 04:39 AM   #4
Becky
Senior Member
 
Becky's Avatar
 
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,172
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

Many of us know about the product Replens but that same company makes another over the counter product called RepHresh. It is a buffered product that helps with the pH issues.

I have used it and it works very well. Its harder to find in drugstores than the more common Replens but you can find it online at drugstore.com

Also, I am sure any pharmacy will order it for you.
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 16 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
Becky is offline   Reply With Quote
Old 03-25-2011, 08:07 AM   #5
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,776
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

From the article:"The gel contains lactic acid to maintain the vaginal pH at about 4.0 (package insert from Han Kook Pharmed Co, Ltd, Seoul, Korea)"
Lani is offline   Reply With Quote
Old 03-25-2011, 08:24 AM   #6
caya
Senior Member
 
caya's Avatar
 
Join Date: Jan 2007
Location: Thornhill, Ontario Canada
Posts: 2,318
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

Thanks Lani I will investigate and take this to my onc. next week as I have my semi-annual appointment.

Unfortunately Replens does not work for me - in fact it causes burning, stinging irritation. My gyn. told me she's had a few women complain of this same irritation. I use coconut oil 2x/day, and it does help, but if there is something new out there that will be better, I am more than willing to try it. Becky I am also interested in the RepHresh - since it is made by the same company, do you know if it contains the same ingredients? I would hesitate to try it if it does for fear of the same burning issues.

all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08

Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
14 Years NED!!

Last edited by caya; 03-25-2011 at 01:30 PM..
caya is offline   Reply With Quote
Old 03-25-2011, 09:49 AM   #7
Becky
Senior Member
 
Becky's Avatar
 
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,172
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

Caya

You'd have to check the box but I have the same problem as you with Replens. I bought the RepHresh a few years ago and had the same problem. I think it is the propylene glycols or surfactants used in such products but it may also be another common ingredient used in these formulations.

So.... I had the same burning problem with RepHresh as I did with Replens (which is a really "too bad" problem to have) as this is rare in general. I am saying that because these products are of great value to most women and I want to state this here because most women do not have this problem.
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 16 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
Becky is offline   Reply With Quote
Old 03-25-2011, 05:48 PM   #8
PatriceH
Senior Member
 
Join Date: Oct 2009
Posts: 98
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

Can someone expand on what is being discussed here? I have had more yeast infections since chemo than ever in my life. I have an onc follow up appointment in a few weeks. I sure would like to have some knowledge so I could ask intelligent questions...On the same day, I have my annual physical with my family doctor...Kind of seems redundant doesn't it?!
PatriceH is offline   Reply With Quote
Old 09-03-2012, 02:45 PM   #9
Christine MH-UK
Senior Member
 
Join Date: Sep 2005
Posts: 414
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

I have tried the lactic acid gel and it does make a difference, although it is a bit messy. There can be a problem with stinging, so it might be easier to ease in with something that gets the vagina in better shape first. I have used vitamin E, as Lani recommended in an earlier posting.

I am writing in because I seem to really struggling to keep on top of bacterial vaginosis, even though one of lactic acid gel's more usual uses is to keep down bacterial vaginosis. I thought it was thrush until I started to have sex again (intercourse apparently is a trigger). In retrospect, I probably always a bit of a suffer since I was always itchy at the end of my period when younger (a telltale sign), but now I seem to struggle to keep the Vietnamese fish sauce smells away. Which is a shame really because things were actually going really well otherwise (painfree sex was a major achievement). I have had one round of metronidazole, but that gave me really bad thrush. The lactic acid gel works, it just stings and can get rather messy.

Has anybody else had increasing problems with bacterial vaginitis? Does it get better?
Christine MH-UK is offline   Reply With Quote
Old 09-04-2012, 06:43 AM   #10
Hopeful
Senior Member
 
Join Date: Aug 2006
Posts: 3,380
Re: pH Balanced Gel for atrophic vaginitis in bc survivors

The name of this product is Clino-san. There was a post on our board by Harrie about it back in 2009. Here is a link that came up when I googled "purchase Clino-san lubricant" : http://her2support.org/vbulletin/sho...eferrerid=1173

Hopeful
Hopeful is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -7. The time now is 05:34 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter