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Old 07-28-2007, 07:31 PM   #1
Julie2
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Join Date: Sep 2005
Posts: 556
worried

My tumor marker (HER-2/new ELISA) has been on the rise for the last 3 months - from 7.5 (in March) to 10.1 (in May) to 13.5 (in June).

Is there a reason to panic ?

Would appreciate views from other survivors who have been in similar situation and suggestions on how to proceed from here would be helpful as well.

Incidentally, I am also getting CA 27-29 monitored. During this same period it has fluctuated from 7.0 (in March) to 8.9 (in May) to 7.7 (in June). Not sure if this data is really useful.
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Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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Old 07-28-2007, 08:17 PM   #2
Bev
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Location: Alexandria, VA
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Hi Julie,

Don't panic but keep testing. My onc doesn't test at all, waits for symptoms. From what I've read you know you have a problem if your scores skyrocket ie, 10 to 30.

I'm not in your shoes, so I hope someone who is can shed some light, Bev
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Old 07-29-2007, 10:14 AM   #3
Vanessa
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Location: Houston, Texas
Posts: 624
My CEA tumour markers had gone down to 1.5 then jumped to 6.5 and then to 12.5. My doctor ordered tests and I had 3 very, very small spots in my lymph nodes, which my doctor jumped on immediately. I should be ending my 3 month round of taxotere added to my Herceptin. I just had a catscan yesterday and will find the results on Tuesday. I was really thankful that my doctor took notice immediately. She knew that my tumour markers seems to correspond with what is going on in my body. It was a far cry from the tumour markers of 273 that I originally had.
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Old 07-29-2007, 04:05 PM   #4
tousled1
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Location: Acworth, GA
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Julie,

My tumor markers were never a good indicator so I relied on my HER2 serum. My benchmark HER2 serum was 10.1 and gradually dropped to 6.3. When it rose to 9.5 I asked my oncologist for a scan even though numbers were still in normal range. It turned out we have lung mets.
I don't want to worry you, but I would ask for a scan. I'm sure it's nothing but better safe than sorry.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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