Quote:
Our results suggest a link between expression of ERβ and endocrine sensitivity,
by increasing PTEN levels and decreasing HER2/HER3 signaling, thereby reducing Akt
signaling with subsequent effects on proliferation, survival and tamoxifen sensitivity of breast
cancer cells. This study supports initiatives to further investigate if ERβ presence in breast
cancer samples is an indicator for endocrine response. Current therapies in ERα positive
breast cancers aim to impair ERα activity with antagonists or by removal of endogenous
estrogens with aromatase inhibitors. Data from this study could be taken as indicative for also
using ERβ as a target in selected groups of breast cancer.
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