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Old 11-19-2010, 05:06 PM   #1
CourtneyL
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Join Date: Aug 2008
Location: San Francisco
Posts: 260
FDA Approves Denosumab (Xgeva) for bone mets!

Great news for us gals with bone mets - the FDA today approved Denosumab (brand name will be Xgeva) for cancers that have metastasized to the bones. According to my onc, Denosumab is a bigger better drug than Zometa - more effective, less side effects. It will be administered once a month in a shot to the arm.

So we're going to give it a roll and see how it goes! Stay tuned...

To read the FDA press release, visit:

http://www.fda.gov/NewsEvents/Newsro.../ucm234346.htm
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4/17/08: Dx Stage IV at age 30 - extensive mets to liver, lungs, and bones. Er/Pr-, Her2+++
April 08-Aug 08:Taxotere, Cytoxan, Herceptin, Zometa - complete response!
Sept 08-Dec 08: Herceptin +Zometa for maintenance.

Jan 09-April 09: Brain mets. Add Tykerb. Watch and wait.
April 09: Gamma Knife 10 brain mets, add Xeloda.
Sept 09: Gamma Knife to 1 brain met.
Nov 09- April 10: Lung progression, add Gemzar to Herceptin, Zometa.
May 10- Sept 10: HER2 Vaccine Trial

Sept 10: Add Tykerb for more brain mets.
Oct 10: Gamma Knife to 7 brain mets.
Dec 10: Switch from Zometa to Denosumab.
Jan 11: Gamma Knife to 3 brain mets.
March 11: Gemzar/Herceptin for lung/bone progression.
April 11: More brain mets - Intrathecal Herceptin
June 11: Ixempra/Herceptin for lung, soft tissue progression.
Aug 11: Gamma Knife
Sep 11: Abraxane/Herceptin
Future: NED

Send me a PM if you'd like to follow my journey on Caringbridge.
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Old 11-19-2010, 06:26 PM   #2
tricia keegan
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Location: Ireland
Posts: 3,463
Re: FDA Approves Denosumab (Xgeva) for bone mets!

I'm so glad for you Courtney and hope it goes well for you

I read a report recently where this drug may be given for osteoprosis, and intend to ask my onc about it when I see her in Dec, anyone else having it for this?
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Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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