another door to shut to keep the "puppy" from escaping to the yard to chase squirrels

[linn65]

Layman's Terms please.......what is the door we need to shut to keep the puppies from chasing those squirrels.

[Lani]

linne, I truly thought those WERE layman's terms.

(((my "puppy" analogy posted previously:
Cancer is like a puppy dog that wants to get out of the house to chase the squirrels. Herceptin is like locking the front door. They puppy may learn it is possible to get out to play with the squirrels by going out the backdoor instead (eg, using her3, EGFR, IGFR, ER, etc paths to escape the blockade of the her2 pathway). Giving chemo is often like accelerating the aging of the puppy. It gets taller and able to jump on the dresser and jump out the window!!

For Stage IVs, it is usually just a question of what they will add next to herceptin if monotherapy is inssufficient to keep it from progressing(like which window/door to close in addition in the case of the puppy) )))

The long words in the abstract describing the ERAD PATHWAY merely describe another window
that needs to be closed to prevent the puppy from escaping to the backyard to wreak havoc chasing the squirrels ie, preventatively blockingia another possible escape route cancer tries to take.Cancer consistently tries to adapt (evolution in real-time) to escape considering previously blocked routes of escape as its goal of relentless growth and migration is not easily thwarted.

GOOD ENOUGH?