Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

[marvass]

Hi Kaiulani and Paul,

Carol is still doing great, now she can talk very well and she is standing at last, even though she had 3 strokes this summer.
From the experience with the mistakes we did with my wife, I would irradiate the tumors and start IT herceptin as fast as possible, the more you delay the bigger are the chances of complications like my wife had. She has not done any intrathecal for the past 6 months and still all MRIs she did lately showed no signs of any tumors at all. Wish you luck. 1.5mg per kilo of IT Herceptin once weekly together with 50mg hydrocortisone seem to work on patients that Herceptin worked everywhere else except their brain.

Paul I am so glad Nina is still doing fine, good luck.
Mario