Omega 3 FA's and L-Carnitine?

[athena453]

Hello All-

My onc advised me to stop Herceptin recently after my LVEF dropped from 60 to "between 40 and 50". I have had 10 weekly doses, including the loading dose as comitant tx with carbo and taxotere following AC as adjuvent tx. I was dx with stage IIIC. ER/PR- her2+ (5.16 FISH).

I met with a nutritionist on Thursday. She has recommended 200mg, then 300mg of COQ10. She also suggested taking an L-Carnitine supplement. I am aware that L-Carnitine effects the ability of fatty acids crossing the mitochondrial membrane to allow for the oxidation of fats.

Any advice or studies on the relationship between Her2 and L-Carnitine, with focus on the Omega 3s?

Two links found from a quick search.

One general information.

One trials with some relation to subject including c-erbB -2.

One link to whey protein. I have seen several trials suggesting positive results. Most of the sports community take whey and a look at the product lists show l-carnitine is added. You might want to look into it further and discuss with your advisor. From memory the percusors of l-carnitine are preent in whey. I will check.

RB


http://www.bodybuildingforyou.com/he...-carnitine.htm

http://www.ncbi.nlm.nih.gov/entrez/q...+breast+cancer

1: Fukumaru S, Horiuchi M, Kobayashi K, Jalil MA, Iijima M, Masuda M, Begum L, Higashi M, Wakana S, Kanzaki T, Saheki T. Related Articles, Links
Abstract Novel mRNA molecules are induced in hypertrophied ventricles of carnitine-deficient mice and belong to a family of up-regulated gene in cells overexpressing c-erbB-2.
Biochim Biophys Acta. 2002 Sep 27;1577(3):437-44.
PMID: 12359334 [PubMed - indexed for MEDLINE]

2: Shennan DB. Related Articles, Links
Abstract Hyposmotically-activated efflux of L-carnitine from a human mammary cancer cell line.
Biosci Rep. 2001 Dec;21(6):779-87.
PMID: 12166827 [PubMed - indexed for MEDLINE]

3: Sachan DS, Dodson WL. Related Articles, Links
Abstract The serum carnitine status of cancer patients.
J Am Coll Nutr. 1987 Apr;6(2):145-50.
PMID: 3584734 [PubMed - indexed for MEDLINE]

4: De Leonardis V, De Scalzi M, Neri B, Bartalucci S, Cinelli P. Related Articles, Links
Abstract Echocardiographic assessment of anthracycline cardiotoxicity during different therapeutic regimens.
Int J Clin Pharmacol Res. 1987;7(4):307-11.
PMID: 3474215 [PubMed - indexed for MEDLINE]

5: Van Hinsbergh VW, Veerkamp JH, Van Moerkerk HT. Related Articles, Links
Abstract Cytochrome c oxidase activity and fatty acid oxidation in various types of human muscle.
J Neurol Sci. 1980 Jul;47(1):79-91.
PMID: 6251173 [PubMed - indexed for MEDLINE]


http://www.lef.org/protocols/prtcl-029a.shtml