Well, I am not sure if you are interested in these articles, but I often wonder the detail of why mouse model fail so often, less than 8% of models translated to clinical trial. Essentially there are a couple of reasons, differences in immune systems, genes expressions, and in tumor mutation paths. Hum, that’s practically everything! But in case you are bored, here they are:
https://www.ncbi.nlm.nih.gov/pmc/art...r0006-0114.pdf
https://www.ncbi.nlm.nih.gov/pmc/art...ihms906208.pdf
https://www.the-scientist.com/news-o...-humans--66223
https://www.npr.org/sections/health-...ried-in-people
Nguyen
Threaded Mode