Anyone heard of Pazopanib?

[Del]

I've been lurking on this website for about a year. I have learned so much (much more than from my oncologist!), and appreciate this site very much! The collective experiences and wisdom on this site are priceless. At age 36, I was diagnosed with breast cancer (in April, 2007), with mets to my liver. Eight rounds of taxotere plus herceptin knocked the mets out of my liver, and I am now NED. I just had my 6-month check-up MRI of my liver, and I get the results on Mon. (July 21). I am very nervous that mets have returned, since I've had an inconsistent ache on my right side just below the rib cage (I'm assuming it's my liver) for the past 3 weeks. I called the office of my second opinion doctor, and they said if I have recurred, it is recommended that I join a clinical trial for Pazopanib. I have never heard of this drug, and the internet searches I have done have not revealed much. It doesn't appear that it has been trialled with breast cancer very much (from what I can find out). Has anyone heard of this, or heard of any results with this drug? Of course I'm wondering if I should just try a different chemo (I'm currently on maintenance Herceptin and Tamoxifen). I will talk to my regular onc about all this on Mon, but wondering if any of that collective wisdom can help me? Thanks in advance!!

[Lani]

pazopanib hydrochloride
The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Code name: GW786034

it is made by Glaxo and seems to be being tried mainly in kidney cancer, ovarian Cancer, and neuroendocrine tumors (eg Islet cell tumors of the pancreas) so far

[Joan M]

Del, I never heard of Pazopanib, but as Lani pointed out it seems to be an anti-angiogenesis drug.

Here's something about trials with Pazopanib from clinicaltrials.gov:

http://clinicaltrials.gov/ct2/results?term=Pazopanib

If you can find out the name of the trial from your second opinion doc you can look it up for more details.

But perhaps there will be not need to go into a trial after all, and your liver is okay. I'll keep my fingers crossed and pray for good results.

Glad you've been lurking around here (lurkers always welcome)and that the information has helped you.

Best, Joan