HonCode

Go Back   HER2 Support Group Forums > her2group
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 09-28-2014, 03:44 AM   #1
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,776
Thumbs up "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for StageIV

patients


Roche breast cancer drug shows 'unprecedented' survival benefit
BY BEN HIRSCHLER
MADRID Sun Sep 28, 2014 3:15am EDT
REUTERS/Aly Song

CREDIT: REUTERS/ALY SONG


Health

(Reuters) - A new breast cancer drug from Roche has shown "unprecedented" survival benefits in a clinical trial, boosting prospects for its widespread use in women with an aggressive form of the disease.

Patients with a type of breast cancer known as HER-2 positive, which makes up about a quarter of all breast cancers, who were given Perjeta on top of older medicine Herceptin and chemotherapy lived 15.7 months longer than those on Herceptin and chemotherapy alone.

ďThe survival improvement of nearly 16 months ... is unprecedented among studies of metastatic breast cancer,Ē lead researcher Sandra Swain from the Washington Hospital Center told the European Society for Medical Oncology annual congress on Sunday.



Perjeta, which was approved by regulators two years ago, was tested in the Roche-backed study in more than 800 women with metastatic disease, whose breast cancer had spread to other parts of the body.

Researchers had previously reported the Perjeta drug regimen significantly extended progression-free survival, or the period of time patients live without their disease worsening, but the final overall survival data has taken longer to collect.

The median overall survival time was 56.5 months for those given Perjeta against 40.8 months for patients taking only the older drugs.

REMARKABLE RESULTS

Javier Cortes, another researcher on the study from the Vall DíHebron Institute of Oncology in Barcelona, said the results were "remarkable" and suggested using Perjeta should be the standard of care for HER-2 positive breast cancer patients.

A favourable reaction from oncologist will underpin expectations of strong sales for Perjeta, which analysts currently expect to sell $3.1 billion a year by 2018, according to consensus forecasts compiled by Thomson Reuters Cortellis.

But it poses a challenge for healthcare providers, since Perjeta is a costly drug and the multiple-drug regimen promises to strain budgets.

For Roche, Perjeta is an important new product that should help defend its position in breast cancer, following the success of Herceptin, which was first approved in 1998.

The company said the latest data would be submitted to regulatory authorities around the world for inclusion in the prescribing information for Perjeta.

Both Herceptin and Perjeta are antibodies designed to block the function of HER2, a protein produced by a cancer-linked gene. Pertuzumab binds to a different part of the same protein, which makes combining the two drugs extra effective.

The safety profile of Perjeta in the long-term analysis presented in Madrid did not reveal any new problems and was consistent with previous evidence, including Perjetaís long-term cardiac safety.

The Swiss drugmaker also has another related drug called Kadcyla, which is also being tested in combination with Perjeta. Some analysts believe Kadcyla's prospects could be curbed if results from that combination are not better than the impressive findings reported this weekend.

(Editing by David Holmes)
Lani is offline   Reply With Quote
Old 09-28-2014, 06:47 AM   #2
linzer
Senior Member
 
Join Date: Jun 2014
Posts: 113
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Yahoo! I'm living proof it works well for early stage given my pCR. I hope that it continues to work wonders for Stage IV sisters especially!!
__________________
---------------
5/15/14 Dx IDC, right breast, 2 cm with 3 cm lymph node ER/PR- Her2+

6/11/14 Taxol / Herceptin / Perjeta

9/17/14 Lumpectomy, axillary lymph node dissection 3/9 nodes showed previous involvement but all clear due to THP!!

9/24/14 NED

10/8/14 AC x 4

12/16/14 rads x 20 WBRT only
linzer is offline   Reply With Quote
Old 09-29-2014, 12:33 AM   #3
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,776
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

MOVING THIS UP AS IT IS THE MOST REMARKABLE HER2 NEWS EVER

THE MOST REMARKABLE BREAST CANCER NEWS EVER

AND ONE OF THE MOST REMARKABLE RESULTS EVER FOR ANY TREATMENT AGAINST ONE OF THE THREE MOST COMMON CANCERS.

FOR ALL THOSE NAY-SAYERS, WHO DEEMED IT DIDN'T MATTER WHAT AGENT OR COMBINATION OF AGENTS GIVEN OR WHAT ORDER GIVEN A STAGE FOR BREAST CANCER PATIENT WAS DOOMED DIE ON AVERAGE 2 YRS AFTER DIAGNOSIS, MUCH SOONER IF HER2 + (HEARD DR HAYES OF U OF MICHIGAN SAY THIS AT A BC MEETING IN May 2005--WHAT A DIFFERENCE 9 YEARS AND LOTS OF RESEARCH MAKES!!!
Lani is offline   Reply With Quote
Old 09-29-2014, 12:38 AM   #4
michka
Senior Member
 
michka's Avatar
 
Join Date: Feb 2007
Location: Paris, France
Posts: 858
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Thank you Lani! This is wonderful news! When will Perjeta be available for all stage IVs? I hope fast now.
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex

12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
michka is offline   Reply With Quote
Old 09-29-2014, 09:40 AM   #5
annettchen
Senior Member
 
Join Date: Mar 2014
Posts: 94
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Thanks! This really is wonderful News! I so hope that all Stage IV sisters get access to this drug ASAP, and that research will continue in leaps and bounds.

Being an incorrigible optimist I say: one day, this beast will be curable, too! I sure hope that will be during my lifetime...
__________________
Annette
----------------------------------------
03/2014: Diagnosed with ER/PR-, HER2+++ MBC (bone mets, oligometastatic)
04/2014: Started 6 cycles of "PHD" (Perjeta, Herceptin, Docetaxol)
07/2014: Finished 6 cycles of PHD; restaging; 2 bone mets are sclerotic - looks like Herceptin and Perjeta is working
10/2014: STABLE!
01/2015: STABLE!
04/2015: STABLE!
08/2015: STABLE!
12/2015: BRAIN METS. BODY STABLE.
annettchen is offline   Reply With Quote
Old 09-29-2014, 01:38 PM   #6
Ellie F
Senior Member
 
Join Date: Feb 2009
Posts: 1,526
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Thanks so much for posting. This is such brilliant news! I just wanted to say that I hope this will be available for women in the UK. So far NICE ( the body we have here which determines which drugs are available for us) has rejected the last 8 new cancer drugs on the basis they don't represent value for money and quality of life!
I hope and pray that this combo will not be viewed in the same way!

Ellie
Ellie F is offline   Reply With Quote
Old 09-29-2014, 09:09 PM   #7
CoolBreeze
Senior Member
 
CoolBreeze's Avatar
 
Join Date: Dec 2009
Posts: 562
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

I'm living proof that it works. I had intractable liver mets: 7 different chemos, half my liver removed, liver ablation, finally chemo starting to destroy my bone marrow, SBRT and then Perjeta and Herceptin combo made me NED in one year.

I got it two months after the FDA approved it for metsters and have been on it ever since. And, I was pronounced NED this summer.

We don't know how long it will work, how long I should be on it, nothing. But I am very very happy with my success and I wish everybody has the same results I have had. And I'm pleased the early stage women get it now too - it might prevent all the suffering I have been through. I would urge all HER2+ women to look into getting it, and don't let the FDA prescribing recommendations stop you. It can be prescribed off-label as mine is - I get Perjeta and Herceptin alone. Doctors have the ability to do that, it does not *have* to be prescribed with a chemo.

Here is a picture of me right before I started Perjeta - I was either on my 6th or 7th chemo and had not started Perjeta yet. And right next to it is one of me today.

I think you can see how much healthier I am, especially if you look at my eyes. They were taken in the same location, by the same person, the same month. (Sorry they are kind of large, I wish I could make them smaller.)

Perjeta is truly a miracle for those whom it works for. I hope it lasts and I'm cured, but if not, I have had a wonderful year I didn't expect, in which I saw my son graduate high school and go to college, and my stepdaughter had my first grandchild. I want that for all women with cancer.

__________________
http://butdoctorihatepink.com

08/17/09 Dx'd.
Multifocal/multicentric IDC, largest 3.4 cm, associated ADH, LCIS, DCIS
HER2+ ER+/PR- Grade 3, Node Negative

10/20/2009: Right mastectomy, reconstruction with TE
12/02/2009: Six rounds TCH, switched to Taxol halfway through due to neuropathy
03/31/2010: Finished chemo
05/01/2010: Began tamoxifen, the worst drug ever
11/18/2010: Reconstruction completed
12/02/2010: Finished herceptin
05/21/2011: Liver Mets. Quit Tamoxifen
06/22/2011: Navelbine/Zometa/Herceptin
10/03/2011: Liver Resection, left lobe. Microwave ablation, right lobe - going for cure!
11/26/2011: C-Diff Superbug Infection, "worst case doctor had seen in 20 years"
03/28/2012: Progression in ablated section of the liver - no more cure. Started Abraxane, continue herceptin/zometa
10/10/2012: Progression continues, started Halaven, along with herceptin and zometa.
01/15/2013: Progression continues, started Gemzar and Perjeta, an unusual combo, continuing with herceptin and zometa
03/13/2013: Quit Gemzar, body just won't handle it. Staying on herceptin, zometa and perjeta.
04/03/2013: CT shows 50% regression in tumor, so am starting back on Gemzar with dose reduction, staying with perjeta/herceptin/zometa. Can't argue with success!
05/09/2013: Discussing SBRT with Radiology due to inability of bone marrow to recover from chemo.
06/07/2013: Fiducial placement for SBRT
07/03/2013: Chemo discontinued, on Perjeta, Herceptin and Zometa alone
07/25/2013: SBRT (gamma knife) begins
08/01/2013: SBRT completed
08/15/2013: STABLE! continuing with Perjeta, Herceptin, Zometa
06/18/2014: ***** NED!!!!***** continuing with Perjeta, Herceptin, Zometa
01/29/2014: Still NED. continuing with Perjeta, Herceptin. Zometa lowered to every 3 months instead of monthly.
11/08/2015: Progression throughout abdomen and lungs. Started TDM-1, aka Kadcyla. Other meds discontinued. Remission was nice while it lasted.

5/27/18: Stable. Kadcyla put me right back in the barn. I have two teeny spots on my lungs that are metabolically inactive, and liver is clean.

Iím beating this MFer. I was 51 when this started and had two kids, 22 and 12. Now Iím 60. My oldest got married and trying to start s family. My youngesg graduates from Caltech this June. My stepdaughter gave me grandkids. Life is fantastic.
CoolBreeze is offline   Reply With Quote
Old 09-29-2014, 09:50 PM   #8
Gift
Senior Member
 
Gift's Avatar
 
Join Date: Jan 2011
Location: Bangkok, Thailand
Posts: 31
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Thank you Lani for such a supportive news.
I'm having one more information in case of PD.

And Coolbreeze ... you look truly healthy and beautiful. Wishing you for many more years NED.
__________________
dx July 2010 with ER 80% PR - Her2 +++, 7 cm tumor
3 rounds AC (stop after round 3 since the tumor didn't shrink)
3 rounds Herceptin until tumor gets smaller to 4 cm
Lumpectomy on 12 Dec 2010
TCH x 4 (6 are planned but low WBC), 35 hits Radiation, and one year Herceptin
Jan 2014: met to bladder and then liver and lungs
Jan 2014: Operation to remove 3 cm. tumor from bladder
May 2014: started Taxotexe & Tratuzumap (either Herceptin or Herculis, being a part of Mylan research)
Oct 2014, 3: finished 8 cycles of Taxotere & Tratuzumap
Oct 2014, 24: only Tratuzumap every 3 weeks
Jul 2015: progress in bladder - operation and keep on Tratuzumap
Dec 2015: progress in bladder still & met to ovaries
Gift is offline   Reply With Quote
Old 09-30-2014, 10:02 PM   #9
Saygoon
Senior Member
 
Saygoon's Avatar
 
Join Date: Jul 2013
Location: Hot Springs, South Dakota
Posts: 158
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Coolbreeze you look amazing! Gives me so much hope. I started Perjeta, Herceptin, Zometa recently hope I get the great results Im hearing from others
__________________
Paula T. (saygoon means dog, yes I am Native)
DX March 2012
Stage IV w/ 5 bone mets to spine 2 on ribs
Herceptin, Zometa, Taxotere and Anasterole and of course radiation
2/14/2014 2 mets on pelvic bone
Stop Anasterole continue on Herceptin and Zometa start radiation (again)
2/24/2014 start T-DM1 continue Herceptin and Zometa
4/28 more radiation that brings total to 5 (10 days ea) - I think I will soon glow in the dark....
6/01/2014 Great news! Rib mets gone, 4 of 5 spine mets showing new bone growth and pelvic mets shrinking.
8/28/2014 T11 on spine is being stubborn started Perjeta, Herceptin, Zometa and Taxol - goodbye hair!
9/04/2014 Tomo therapy - pain finally gone
1/3/2015 - starting New Year out as still stable. Feeling positive
2/23/2015 - problems with left leg, bone met flaring up - MORE radiation Whew!
2/24/2015 Stress fracture in right side of pelvic - (great just great) back to wheelchair then walker then.....
2/26/2015 Off Taxol!! Still on Perjeta, Herceptin and Hormone Blocker starting to feel a little more human.
4/10/2015 Cancer has spread to spinal fluid - not sure where I go from here
6/29/2015 Omaya Port placed,begin IT Herceptin on 7/7/2015
Saygoon is offline   Reply With Quote
Old 10-02-2014, 08:56 AM   #10
kk1
Senior Member
 
Join Date: Sep 2005
Posts: 181
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Don't make those pictures smaller....they bring us all so much hope. You look so stunning on the right --it brings tears to my eyes knowing that after all you have been through you are able to look and feel so good again.
__________________
KK1
April 2004 de novo metastatic left breast 1.5cm her2++,er+/pr+ with 2 small liver mets
weekly taxotere,herceptin, xeloda
Sept 2004 NED-3 herceptin, zoladex,aromasin
Dec 2006 recurrence in liver
Feb. 2007 liver resection left lobe removed-herceptin, zoladex, switch to Arimidex
NED 16 months added zometa
May 2008 new lesion in liver 15mm Tykerb/Xeloda/Herceptin
July 2008 stable...yeah!
Sept 2008 NED again !!!
Jan 2009 fell off the wagon again spot back in the liver and fell out of menopause.
Feb 2009 RFA and 2nd liver resection to remove spot ---back on the NED wagon again continue Tykerb, Herceptin.
March 2009- oophrectomy added Femara and bi-annual Zometa
May 2009- scans clear but suspect lung nodule
June 2009- Lung VAT wedge resection to remove nodule---fungus ball not cancer!! phew
Aug 2009- NED
Nov 2009-scans again clear YAHOO!
March 2010- scans clear continue Tykerb, Herceptin, Femara, Zometa Q6mo
Nov 2009-Nov 2019 scans clear done every 6 months

Miracles do happen
Stage IV 15 years last 10+ NED
kk1 is offline   Reply With Quote
Old 10-02-2014, 11:49 AM   #11
Nurse4u2day
Senior Member
 
Nurse4u2day's Avatar
 
Join Date: Feb 2014
Location: California
Posts: 426
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Coolbreeze your picture and your fight are just amazing! All you stage IV ladies are amazing. I hope that this new study is able to bless so many cancer Dx.
I was stage 3c with a highly agressive cancer beyond just her2 and needless to say there is always that part if me that fears a stage IV Dx ... To know that there are long term survivors as well as new drugs and trials to help us all remain NED is of some comfort.
__________________
11/13 Dx IDC left breast
11/19/2013 Inflammatory Breast Cancer stage 3c grade 2 Er- Pr- her2+++
Node involvement suspected based on CT
12/13 port placed
12/13 neoadjuvant DD AC xs 4 rounds started
02/14 taxol/herceptin started every week xs 12 rounds
Herceptin for 1 year
Ki67=23%
BRCA1&2 negative
5/06/14 last round taxol/herceptin. Chemo done!!!
5/07/14 clear CT scan
6/11/14 Bilateral Mastectomy Done
6/15/14 8mm tumor post chemo. Removed by bmx
6/15/14 lymph nodes 0/9
6/15/14 officially Cancer Free
7/11/14 emergency surgery to left breast . Wound refused to heal and broke open. New TE placed
7/28/14 emergency medical procedure now to right breast( post op 6 weeks mastectomy ) wound opens.
8/25/14 - 10/07/14 Radiation
11/24/14 CT of Brain clear
01/23/15 One year Herceptin Complete
02/04/15 Diep done
5/01/15 1 year Ct scan- mass in thymus
6/23/15 repeat CT mass in thymus still present
6/30/15 biopsy thymus 7/03/15 mass Benign! Diagnoses Thymic hyperplasia rebound ( chemo at fault, no long term health effects)
7/08/15 phase 2 diep
11/23/15 phase 2b ( reconstructive surgery with lipo)
03/05/18 Vinnie Myer 3 D nipple tattoos complete.
11/19/2018 5 years since Dx of IBC stage 3c remain NED.
Nurse4u2day is offline   Reply With Quote
Old 10-02-2014, 01:36 PM   #12
jaykay
Senior Member
 
Join Date: Oct 2012
Posts: 638
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Ah, Ann - you look amazing! So happy for you and all the others who have benefited from perjeta
__________________
March, 2000: 48, Post menopausal (5 yrs HRT) Left breast, IDC 3mm/DCIS 1.6cm, ER+/PR-/Her2+++, mod differentiated, MIB low, lumpectomy, node neg via SNB, rads=33 Stage 1a
June, 2000: Tamox 4.5 years,Femara for 5 years (end in Jan. 2010)
Sept, 2012: 61, Via mamm, ultrasound, biopsy, right breast, 2.3cm tumor, ER+/PR-/Her2+++, poorly diff, KI67 60-70%
BRCA 1 and 2 negative
October, 2012: Bi Mast with tissue expanders, port placement
Final Path: IDC 2.8cm, DCIS, 1/4 sentinal nodes positive (@#$%). Stage IIB
Nov 29, 2012: Begin TCH/6x/every 3 wks, H for 1 year/every 3 weeks.
March 14, 2013: Finished chemo
April 9, 2013: Begin radiation 28x
May 22, 2013: Finished rads
June 1st, 2013: Started Aromasin for 5 yrs.
July 15, 2013: Switched to Letrozole (Femara). Probably for the rest of my life
October 16, 2013: Exchange surgery
October 31, 2013: Finished Herceptin
December 5, 2013: Port removed
Glad this year is over!
jaykay is offline   Reply With Quote
Old 10-03-2014, 09:58 PM   #13
Mtngrl
Senior Member
 
Mtngrl's Avatar
 
Join Date: May 2011
Location: Denver, CO
Posts: 1,427
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

I'm on Herceptin and Perjeta too, though I started out with no chemo and now I'm taking Xeloda, which I'm tolerating well.

The best thing about the "mab" drugs (stands for "monoclonal antibody") is they allow for a near-normal quality of life for most folks (though of course not all.) If you don't get any heart toxicity or lung problems, you can breeze right through them.

Ann, thanks so much for the pictures. You look fantastic. I love your long, thick hair. And Lani, keep the good news coming!
__________________
Amy
_____________________________
4/19/11 Diagnosed invasive ductal carcinoma in left breast; 2.3 cm tumor, 1 axillary lymph node, weakly ER+, HER2+++
4/29/11 CT scan shows suspicious lesions on liver and lungs
5/17/11 liver biopsy
5/24/11 liver met confirmed--Stage IV at diagnosis
5/27/11 Begin weekly Taxol & Herceptin for 3 months (standard of care at the time of my DX)
7/18/11 Switch to weekly Abraxane & Herceptin due to Taxol allergy
8/29/11 CT scan shows no new lesions & old lesions shrinking
9/27/11 Finish Abraxane. Start Herceptin every 3 weeks. Begin taking Arimidex
10/17/11--Brain MRI--No Brain mets
12/5/11 PET scan--Almost NED
5/15/12 PET scan shows progression-breast/chest/spine (one vertebra)
5/22/12 Stop taking Arimidex; stay on Herceptin
6/11/12 Started Tykerb and Herceptin on clinical trial (w/no chemo)
9/24/12 CT scan--No new mets. Everything stable.
3/11/13 CT Scan--two small new possible mets and odd looking area in left lung getting larger.
4/2/13--Biopsy of suspicious area in lower left lung. Mets to lung confirmed.
4/30/13 Begin Kadcyla/TDM-1
8/16/13 PET scan "mixed," with some areas of increased uptake, but also some definite improvement, so I'll stay on TDM-1/Kadcyla.
11/11/13 Finally get hormone receptor results from lung biopsy of 4/2/13. My cancer is no longer ER positive.
11/13/13 PET scan mixed results again. We're calling it "stable." Problems breathing on exertion.
2/18/14 PET scan shows a new lesion and newly active lymph node in chest, other progression. Bye bye TDM-1.
2/28/14 Begin Herceptin/Perjeta every 3 weeks.
6/8/14 PET "mixed," with no new lesions, and everything but lower lungs improving. My breathing is better.
8/18/14 PET "mixed" again. Upper lungs & one spine met stable, lower lungs less FDG avid, original tumor more avid, one lymph node in mediastinum more avid.
9/1/14 Begin taking Xeloda one week on, one week off. Will also stay on Herceptin and Perjeta every three weeks.
12/11/14 PET Scan--no new lesions, and everything looks better than it did.
3/20/15 PET Scan--no new lesions, but lower lung lesions larger and a bit more avid.
4/13/15 Increasing Xeloda dose to 10 days on, one week off.
7/1/15 Scan "mixed" again, but suggests continuing progression. Stop Xeloda. Substitute Abraxane every 3 weeks starting 7/13.
10/28/15 PET scan shows dramatic improvement everywhere. All lesions except lower lungs have resolved; lower lungs noticeably improved.
12/18/15 Last Abraxane. Continue on Herceptin and Perjeta alone beginning 1/8/16.
1/27/16 PET scan shows cancer is stable.
5/11/16 PET scan shows uptake in some areas that were resolved on the last two scans.
6/3/16 Begin Kadcyla and Tykerb combination
6/5 - 6/23 Horrible diarrhea from K&T together. Got pneumonia.
7/15/16 Begin Kadcyla only every 3 weeks.
9/6/16 Begin radiation therapy on right lung lesion that caused the pneumonia.
10/3/16 Last of 12 radiation treatments to right lung.
11/4/16 Huffing and puffing, low O2, high heart rate, on tiniest bit of exertion. Diagnosed as radiation pneumonitis. Treated with Prednisone.
11/11/16 PET scan shows significant improvement to radiated part of right lung BUT a bunch of new lung lesions, and the bone met is getting worse.
11/22/16 Begin Eribulin and Herceptin. H every 3 weeks. E two weeks on, one week off.
3/6/17 Scan shows progression in lungs. Bone met a little better.
3/23/17 Lung biopsy. Tumor sampled is ER-, PR+ (5%), HER2+++. Getting Herceptin and Perjeta as a maintenance treatment.
5/31/17 Port placement
6/1/17 Start Navelbine & Tykerb
Mtngrl is offline   Reply With Quote
Old 10-04-2014, 11:12 AM   #14
jacqueline1102
Senior Member
 
Join Date: Apr 2012
Posts: 177
Re: "remarkable results" presented for adding Perjeta(pertuzumab)to Herceptin for Sta

Greetings all,

Count me in on this one. I started the Perjeta/Herceptin combo on August 1, 2012 and have been NED since. Enjoying family and friends, working fulltime, and traveling. All is good thus far. How wonderful news for all of you. And Ann, I love your blog. You are a true advocate; seeing the big picture of this whole breast cancer crap. May us Stage IV women get through October. Peace to all of you.

Take care,

Jackie
__________________
10/11 IBC Stage IV; 1 liver met 4.6 cm.
10/11-2/12 TCH for 6 rounds
3/12 Right MRM
5/12-7/12 33 Radiation treatments
8/1/12 Started Perjeta along with the Herceptin
10/12 Scans said NED for first time
5/15 UWSeattle Vaccine Trial 3 months
12/16 Scans still show NED. Herceptin and Perjeta continue indef.
8/17 Taken off Perjeta;staying on Herceptin. Still NEAD.
3/18 Still NEAD
8/19 Now on Subcutaneous Herceptin
jacqueline1102 is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -7. The time now is 03:56 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter