breaking news from ASCO--new drug penetrates BBB , effectively combines w TDM1,is new

[Lani]

alternative for Stage IVs running out of alternatives!

PUBLIC RELEASE: 29-MAY-2015
ONT-380 has stage IV HER2+ breast cancer patient 'worrying about normal stuff again'
UNIVERSITY OF COLORADO DENVER

IMAGE
IMAGE: AT ASCO 2015, VIRGINIA BORGES, M.D., M.M.SC., AND COLLEAGUES REPORT PROMISING CLINICAL TRIAL RESULTS OF ONT-380 AGAINST HER2+ BREAST CANCER. view more

CREDIT: UNIVERSITY OF COLORADO CANCER CENTER

Promising clinical trial results presented at the American Society for Clinical Oncology (ASCO) Annual Meeting 2015 show activity of the investigational anti-cancer agent ONT-380 against HER2+ breast cancer, in one case specifically against brain metastases and in another case in overall survival of heavily pretreated HER2+ breast cancer patients.

"I am thrilled to have been able to offer this therapy to a patient in her early 40s. She didn't have any other great treatment options that we would have expected to have any meaningful impact, especially on her brain. Now she's been on the study over a year. The mets in her body are gone and the brain lesion has shrunk down to a little nubbin. She's living a normal life, fretting about the family business and how the kids are doing - normal stuff," says Virginia Borges, MD, MMSc, director of the Breast Cancer Research Program and Young Women's Breast Cancer Translational Program at the University of Colorado Cancer Center and one of the study's authors.

Both sets of results being presented are from ongoing phase 1b clinical trials of ONT-380, one in combination with the drug TDM-1, and the other in combination with capecitabine and/or trastuzumab. Women on these studies include those whose disease had progressed after at least two previous rounds of therapy (sometimes including previous drugs used to target HER2).

In the first study of ONT-380 with TDM-1, all 8 evaluable patients experienced more than 50 percent reduction in primary brain tumor size.

"This drug has the potential to be the long-awaited, needed therapy that targets brain metastases in HER2+ brain cancer, and could even someday be used to prevent brain metastases in the first place," says Borges.

The second study presents overall response rates from a similar, ongoing phase 1b clinical trial of ONT-380 with capecitabine and/or trastuzumab. Of 8 heavily pretreated patients enrolled on the study, 4 showed partial response (reduction in tumor size of more than 30 percent), 2 achieved stable disease, and 2 progressed.

In about 25 percent of the 1-in-8 women who will develop breast cancer during their lifetimes, the HER2 gene creates an abnormal amount of HER2 protein, which acts as a "receptor" for human epidermal growth factor. The presence of more HER2 receptors allows a cell to trap more growth-promoting hormones, which tells the cell to grow in an out-of-control, cancerous way.

ONT-380, invented by Array Biopharma in Boulder, CO and now being developed by Oncothyreon in Seattle, WA, is a small molecule inhibitor of the HER2 growth factor receptor. The drug works by targeting the HER2 "tyrosine kinase" - a link in the chain of communication that allows HER2 receptors to signal the growth of the cell. The fact that it is a small molecule means the drug is able to pass through the blood-brain barrier to act against brain metastases of the disease. HER2+ breast cancer is more likely to affect younger women and also more likely than other breast cancers to metastasize specifically to the brain.

"Usually we expect the results of a phase 1 clinical trial to give us data that we can use to guide the results of future treatments. This is a great case in which, for many of these patients, the results were immediate. There are women who are alive today because of this drug," Borges says.

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[Jackie07]

Wow! That sounds promising! Thanks, Lani.

[linzer]

This sounds very promising! Thank you for sharing, Lani! Linda

[donocco]

I did some research on ONT-380. It only inhibits Her2Neu so the diarrhea is nothing like Lapatanib. It penetrates the blood brain barrier. Apparently some of the phase one studies were done on patients with brain mets. Ont=380 was given combined with other drugs. None of the patients with brain mets progressed. There was one remission, one partial remission and all of the other patients with brain mets stayed stable.

The dosage given was 300mg orally twice daily. The side effects were nausea, some diarrhea rash and increase in liver enzymes.

Paul

[Dakini52]

Thanks for sharing this hopeful news. for all of us who already have brain mets or could develop them it is so nice that this type of research is being done.

[Pamelamary]

Thanks Lani!

[Mtngrl]

Great news!

[Carol Ann]

Wonderful!

CA

[Lani]

donocco--according to today's lecture on neratinib it is a tyrosine kinase inhibitor which irreversibly prevents phosphorylation of her1 2 and 4 (her 3 does not have an active intracellular domain which requires phosphorylation for activation as the other 3 her receptors do)

The worst side effect was diarrhea which caused some to discontinue use in the first 1-2 months, but they later found a workaround , a medication which resolved the diarrhea problems when taken regularly and discontinuations have fallen off.

THE RESULTS REPORTED SEEMS PHENOMENAL ESPECIALLY as they were even better for FOR ER+HER2+,.a group which traditionally experiences less pCRs from her2blockade with monoconal antibodies or their combinations with or without chemo.

[sarah]

Thanks Lani, this is very promising news.
sarah