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Old 12-27-2020, 10:09 AM   #1
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Covid vaccines and cancer patients

Very little information at the moment, I'll keep update this as I see more.





What is the ability of cancer patients to mount an immune response following vaccination?

Data on humoral and cellular immune response to antiviral vaccination in cancer patients are scarce, and mostly address the issue of influenza vaccination [1,2]. Observational clinical studies indicate that lower mortality and morbidity rates from influenza are observed in cancer patients receiving influenza vaccination [II] [3], suggesting an efficient immune response.

In lung and breast cancer patients, the humoral immune response to vaccination appears adequate, although not all patients were receiving chemotherapy [IV] [4,5]. In a study of patients with various solid tumours, the response to vaccination was better than in patients with lymphoma [IV] [6].

In patients receiving chemotherapy, seroconversion and seroprotection rates are expected to be lower than in the general population [IV] [7], but not in patients receiving single-agent immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) [IV] [8].

In patients receiving chemotherapy, multiple doses of vaccine might help to reach adequate seroconversion and seroprotective rates. As an illustration, in a non-randomised Phase II study on 65 patients with solid tumours receiving chemotherapy (+/- molecular targeted agents) during the 2009 influenza season, 5% of patients had vaccine strain titres of specific haemagglutination inhibition antibodies that were ≥1:40 at baseline. After one and two doses of AS03A-adjuvanted H1N1v vaccine, seroprotection rates (i.e. the proportion of participants with antibody titres ≥1:40) were 48% and 73%, respectively, and seroconversion rates were 44% and 73%, respectively [III] [9].

Whenever possible, the administration of the vaccine should be performed before initiation of chemotherapy [V] [2]. In patients who have already initiated chemotherapy, the existing data do not support a specific timing of administration with respect to chemotherapy infusions [III] [2, 9].
In order to generate protective immunity following vaccination, intact host immunity is needed, particularly with respect to antigen presentation, B- and T-cell activation. In this context, vaccination may be less effective in patients receiving anti–B-cell antibodies or intensive chemotherapy (e. g. induction or consolidation chemotherapy for acute leukaemia) because the antibody response may be low, due to B-cell depletion, though the role and potential protective effect of T-cell immunity has not been studied extensively [V] [2].

The level of evidence is weak, due to the small number of studies and their methodology; placebo-controlled randomised controlled trials of antiviral vaccination among adults with cancer being often considered ethically questionable [V] [2].
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Old 01-14-2021, 12:10 PM   #2
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Re: Covid vaccines and cancer patients

Proably should read the whole article, there are other useful info in it, beside snippets below.



"...“Most cancer patients, even those in treatment, should go ahead and get vaccinated when it becomes available,” he said. “Ideally between cycles of systemic immunosuppressive therapy.”

Patients in treatment should work with their oncologists to time the two-shot vaccine, he said.

“Using the flu vaccine as a prototype, it seems to be significantly better to give the vaccine between cycles rather than at the same time as the cytotoxic [cell-killing] therapy,” he said....

...I would prioritize patients with active cancer as well as those on active cancer therapy,” he said. “We’re fighting a pandemic where cancer patients are at three, four, or five times greater risk for fatality than others. It’s a risk-benefit equation. Their risk from COVID-19 is exceptionally high...

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Old 01-16-2021, 11:53 AM   #3
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Re: Covid vaccines and cancer patients


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Old 01-20-2021, 03:01 PM   #4
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Re: Covid vaccines and cancer patients

Not sure how I stumbled across the info that NSAOD pain killer impacts immune respond from vaccine. I thought I saw something similar on CDC, but for some strange reason, couldn't find it again yet. An ultra short summary of the two pubmed articles below is:

NSAID class pain killer (anti inflammatory) block the Cox-2 pathway and in turn blocks the final transformation of B lymphocytes to become plasma producing cells which produce antibody. Reduction of antibody implies a weak immune respond.

Incidentally, lots of conventional drugs are cox2 inhibitor. Natural anti inflammatory substance such as tumeric/curcurmin also is a cox2 inhibitor.


From CA Orange County:


“Q. Should I take Tylenol or Motrin before my vaccination?
A. If you regularly take aspirin, acetaminophen (e.g., Tylenol) and ibuprofen (e.g., Motrin, Advil) for other medical conditions, continue to do so as directed by your physician or as needed. Otherwise, do not pre-medicate.
Taking over-the-counter medications such as acetaminophen and ibuprofen before receiving a vaccine may reduce its ability to work and blunt your immune response to the vaccine. After the vaccination, don’t hesitate to take an over-the-counter medication if you have symptoms that make you uncomfortable.”

“…Unless your health care provider tells you otherwise, it’s best not to take pain relievers one or two days before the flu vaccine and for a week afterward,” said David J. Topham, Ph.D., a study author and professor in the Center for Vaccine Biology and Immunology at URMC.

What about low-dose aspirin? Individuals who take aspirin for cardiovascular or vascular disease should talk to their doctors before stopping even low-dose aspirin. And people who take medications such as Celebrex for arthritis or other chronic pain also should consult their physicians…

The use of NSAIDs may adversely influence the efficacy of vaccines, especially in the immunocompromised, elderly and when vaccines are weakly immunogenic…”


I believe the research below are the reference science for above guide lines.


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Old 01-22-2021, 09:40 PM   #5
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Re: Covid vaccines and cancer patients

Well, to be fair for most people Coronavirus poses virtually no risk at all, so any risk that comes with the vaccine is significant.
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