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Old 12-27-2020, 10:09 AM   #1
Nguyen
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Join Date: Nov 2005
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Covid vaccines and cancer patients

Very little information at the moment, I'll keep update this as I see more.

Nguyen


https://ascopost.com/issues/december...id-19-vaccine/

https://www.asco.org/asco-coronaviru...atients-cancer

https://www.esmo.org/covid-19-and-ca...19-vaccination

What is the ability of cancer patients to mount an immune response following vaccination?

Data on humoral and cellular immune response to antiviral vaccination in cancer patients are scarce, and mostly address the issue of influenza vaccination [1,2]. Observational clinical studies indicate that lower mortality and morbidity rates from influenza are observed in cancer patients receiving influenza vaccination [II] [3], suggesting an efficient immune response.

In lung and breast cancer patients, the humoral immune response to vaccination appears adequate, although not all patients were receiving chemotherapy [IV] [4,5]. In a study of patients with various solid tumours, the response to vaccination was better than in patients with lymphoma [IV] [6].

In patients receiving chemotherapy, seroconversion and seroprotection rates are expected to be lower than in the general population [IV] [7], but not in patients receiving single-agent immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) [IV] [8].

In patients receiving chemotherapy, multiple doses of vaccine might help to reach adequate seroconversion and seroprotective rates. As an illustration, in a non-randomised Phase II study on 65 patients with solid tumours receiving chemotherapy (+/- molecular targeted agents) during the 2009 influenza season, 5% of patients had vaccine strain titres of specific haemagglutination inhibition antibodies that were ≥1:40 at baseline. After one and two doses of AS03A-adjuvanted H1N1v vaccine, seroprotection rates (i.e. the proportion of participants with antibody titres ≥1:40) were 48% and 73%, respectively, and seroconversion rates were 44% and 73%, respectively [III] [9].

Whenever possible, the administration of the vaccine should be performed before initiation of chemotherapy [V] [2]. In patients who have already initiated chemotherapy, the existing data do not support a specific timing of administration with respect to chemotherapy infusions [III] [2, 9].
In order to generate protective immunity following vaccination, intact host immunity is needed, particularly with respect to antigen presentation, B- and T-cell activation. In this context, vaccination may be less effective in patients receiving anti–B-cell antibodies or intensive chemotherapy (e. g. induction or consolidation chemotherapy for acute leukaemia) because the antibody response may be low, due to B-cell depletion, though the role and potential protective effect of T-cell immunity has not been studied extensively [V] [2].

The level of evidence is weak, due to the small number of studies and their methodology; placebo-controlled randomised controlled trials of antiviral vaccination among adults with cancer being often considered ethically questionable [V] [2].
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Old 01-14-2021, 12:10 PM   #2
Nguyen
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Re: Covid vaccines and cancer patients

Proably should read the whole article, there are other useful info in it, beside snippets below.

Nguyen

https://www.fredhutch.org/en/news/ce...ronavirus.html

"...“Most cancer patients, even those in treatment, should go ahead and get vaccinated when it becomes available,” he said. “Ideally between cycles of systemic immunosuppressive therapy.”

Patients in treatment should work with their oncologists to time the two-shot vaccine, he said.

“Using the flu vaccine as a prototype, it seems to be significantly better to give the vaccine between cycles rather than at the same time as the cytotoxic [cell-killing] therapy,” he said....

...I would prioritize patients with active cancer as well as those on active cancer therapy,” he said. “We’re fighting a pandemic where cancer patients are at three, four, or five times greater risk for fatality than others. It’s a risk-benefit equation. Their risk from COVID-19 is exceptionally high...


"
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Old 01-16-2021, 11:53 AM   #3
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Re: Covid vaccines and cancer patients

https://www.medscape.com/viewarticle/943972

https://www.cell.com/cancer-cell/ful...108(21)00001-5
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Old 01-20-2021, 03:01 PM   #4
Nguyen
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Re: Covid vaccines and cancer patients

Not sure how I stumbled across the info that NSAOD pain killer impacts immune respond from vaccine. I thought I saw something similar on CDC, but for some strange reason, couldn't find it again yet. An ultra short summary of the two pubmed articles below is:

NSAID class pain killer (anti inflammatory) block the Cox-2 pathway and in turn blocks the final transformation of B lymphocytes to become plasma producing cells which produce antibody. Reduction of antibody implies a weak immune respond.

Incidentally, lots of conventional drugs are cox2 inhibitor. Natural anti inflammatory substance such as tumeric/curcurmin also is a cox2 inhibitor.

Nguyen

From CA Orange County:

http://www.ucihealth.org/covid-19/co...0the%20vaccine.

“Q. Should I take Tylenol or Motrin before my vaccination?
A. If you regularly take aspirin, acetaminophen (e.g., Tylenol) and ibuprofen (e.g., Motrin, Advil) for other medical conditions, continue to do so as directed by your physician or as needed. Otherwise, do not pre-medicate.
Taking over-the-counter medications such as acetaminophen and ibuprofen before receiving a vaccine may reduce its ability to work and blunt your immune response to the vaccine. After the vaccination, don’t hesitate to take an over-the-counter medication if you have symptoms that make you uncomfortable.”
-------------
https://www.urmc.rochester.edu/news/...lenol-for-mild

“…Unless your health care provider tells you otherwise, it’s best not to take pain relievers one or two days before the flu vaccine and for a week afterward,” said David J. Topham, Ph.D., a study author and professor in the Center for Vaccine Biology and Immunology at URMC.

What about low-dose aspirin? Individuals who take aspirin for cardiovascular or vascular disease should talk to their doctors before stopping even low-dose aspirin. And people who take medications such as Celebrex for arthritis or other chronic pain also should consult their physicians…

The use of NSAIDs may adversely influence the efficacy of vaccines, especially in the immunocompromised, elderly and when vaccines are weakly immunogenic…”

------------

I believe the research below are the reference science for above guide lines.

https://pubmed.ncbi.nlm.nih.gov/19941994/

https://pubmed.ncbi.nlm.nih.gov/20050331/
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Old 01-22-2021, 09:40 PM   #5
AlfredoLong
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Re: Covid vaccines and cancer patients

Well, to be fair for most people Coronavirus poses virtually no risk at all, so any risk that comes with the vaccine is significant.
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Old 05-14-2021, 07:59 AM   #6
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Re: Covid vaccines and cancer patients

>Well, to be fair for most people Coronavirus poses virtually no risk at all, so any risk that comes with the vaccine is significant.

The above statement is so manipulative, irresponsible, and selfish!
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Old 07-01-2021, 06:45 AM   #7
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Re: Covid vaccines and cancer patients

Immunogenicity of SARS-CoV-2 messenger RNAvaccines in patients with cancer

https://reader.elsevier.com/reader/s...20210701133648

SUMMARYPatientswithcancerexperienceahigherburdenof SARS-CoV-2infection,diseaseseverity,complications,andmortal ity, than the general population. SARS-CoV-2 mRNA vaccines are highly effective in the general popula-tion; however, few data are available on their efficacy in patients with cancer. Using a prospective cohort, weassessed the seroconversion rates and anti-SARS-CoV-2 spike protein antibody titers following the first andsecond dose of BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines in patients with cancer in US and Europefrom January to April 2021. Among 131 patients, most (94%) achieved seroconversion after receipt of two vac-cine doses. Seroconversion rates and antibody titers in patients with hematological malignancy were signifi-cantly lower than those with solid tumors. None of the patients with history of anti-CD-20 antibody in the6monthsbeforevaccinationdevelopedantibodyrespon se.Antibodytiterswerehighestforclinicalsurveillanc eor endocrine therapy groups and lowest for cytotoxic chemotherapy or monoclonal antibody groups.
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Old 07-31-2021, 05:18 PM   #8
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Serologic Status and Toxic Effects of the SARS-CoV-2 BNT162b2 Vaccine in Patients Und

Serologic Status and Toxic Effects of the SARS-CoV-2 BNT162b2 Vaccine in Patients Undergoing Treatment for Cancer

https://jamanetwork.com/journals/jam...rticle/2781608

Key Points

Question What is the serologic status and incidence of adverse effects in patients with cancer who are receiving therapy after administration of the SARS-CoV-2 BNT162b2 vaccine?

Findings This cohort study evaluated serologic status and safety of the BNT162b2 vaccine in 232 patients receiving active treatment for cancer and 261 health care workers who served as controls. After the first dose of the vaccine, 29% of the patients were seropositive compared with 84% of the controls; after the second dose, the seropositive rate of the patients reached 86%, and reported adverse events resembled those of healthy individuals.

Meaning The SARS-CoV-2 BNT162b2 vaccine appears to be safe with satisfactory levels of seropositivity in patients undergoing treatment for cancer, although protection may occur later compared with the healthy population.
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Old 08-11-2021, 08:40 PM   #9
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Re: Covid vaccines and cancer patientsDurability of Response to SARS-CoV-2 BNT162b2 V

Durability of Response to SARS-CoV-2 BNT162b2 Vaccination in Patients on Active Anticancer Treatment

https://jamanetwork.com/journals/jam...tm_term=081121

Hopefully, booster shot (third dose) for at risk people will be authorized this Friday. This would go a long way (for most people) in improving/restore vaccine respond.
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Old 08-20-2021, 09:09 AM   #10
Nguyen
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First long-acting antibody combination to prevent COVID-19

I thought this is great news for those of us who don’t produce (or produce “enough”) antibodies after vaccine. Though don’t count on it and skip vaccine. Antibody level is only one component our immune defense.

https://www.astrazeneca.com/media-ce...-endpoint.html
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