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Old 07-21-2011, 04:44 AM   #1
Lauriesh
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Join Date: Oct 2005
Location: Lakeville, Minnesota
Posts: 199
New Vaccine trial

Hi, just wanted to let everyone know about a new Her2 vaccine trial that has just started recruiting patients. It is in Seattle.

It is trial # NCT01355393

It is for stage 2 and 3 who have completed treatment and stage 4, who are NED or stable bone only.

Laurie
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Old 07-21-2011, 05:15 AM   #2
Ellie F
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Re: New Vaccine trial

Thank you for posting. I have been interested in vaccine trials for ages but never seem to find the right one or qualify! Will have a look at this one.

Ellie
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Old 07-21-2011, 03:57 PM   #3
Lauriesh
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Re: New Vaccine trial

I spoke to them about the trial, and found out that if I decide to do it ( I am stage 4, and NED for 5 months) I will have to stop Herceptin and tykerb for 3 months, while I am getting the vaccine.

I am not sure what to do. I want to do the trial, but am nervous about stopping treatment for 3 months.

any opinions?

Laurie
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Old 07-21-2011, 04:30 PM   #4
her2 newBEE
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Join Date: Apr 2011
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Re: New Vaccine trial

Just my $0.02, but it seems that your current regimen of Tykerb + Herceptin is working splendidly! if you are stage 4 and now NED, you can't ask for better response than that.

I would be reluctant to come off of a regimen that you know is working for one that you hope will work. Obviously, your doctors can give you the best advice, but I would think twice about coming off something that seems to be working so well.
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Old 07-27-2011, 12:47 PM   #5
Joan M
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Re: New Vaccine trial

I spoke with a women in Seattle about a month ago regarding a Phase 3 trial which I then learned had just closed to enrollment. She wanted instead to recruit me for the trial posted here which is a Phase 1-2 trial to determine vaccine dosage. There are 3 arms.

Joan
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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Old 07-27-2011, 12:52 PM   #6
Ellie F
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Re: New Vaccine trial

Thanks Joan I wondered if this trial was the one Steph had referred to earlier this year?

Ellie
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