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Old 06-22-2011, 04:32 PM   #1
Chelee
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Need some help...

I've been going through a rough time due to a problem I've ran into with my lungs. I have compromised lung function to begin with. Not long ago my onc made an error with Navelbine/Herceptin and it really set me back. I've been on oxygen for 3 months now. I'm now able to function mostly without it unless I have to walk too far. This has excluded me from the T-DM1 trial since I'm on oxygen.

My last PET/CT shows progression/uptake in both hips and pelvis. I need to start chemo. CA27.29 still going up...I have to get started which worries me since my lungs aren't fully recovered. I have been holding off chemo for too long but have to do something now. Currently I'm only on Herceptin/Zometa/Femara. Any idea's/thoughts on which chemo I could try at a lower dose that might not be so harsh on my lungs...yet still stop the progression with bone mets?

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 06-22-2011, 07:28 PM   #2
mmoons
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Re: Need some help...

Chelee-

I do not have any advice to offer. There are so many brilliant woman here...someone will have advice for you.

I am so sorry for your struggles. I am lifting you up in prayer and sending you hugs.

Maureen
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IDC & DCIS, HER2+++ Diagnosis: October 1, 2008
  • Tumor: 6.8 centimeters, never showed on mammograms
  • ER-/PR-
  • November 2008: Sentinal Lymph node surgery. 6 out of 9 lymph nodes with cancer
  • Stage IIIc
  • Lapatinib Clinical Trial start: November, 2008
  • Surgery: May 5, 2009
  • Started Herceptin: May 19, 2009
  • Started Radiation (33 rounds): June 10, 2009
  • September 2009: Moved to Michigan to be closer to family
  • 12/09 - still on Herceptin until May 2010
  • August 2010: Port out, port out, port out port out port port port out port ooooout...da da da dant! (to the music of the Pink Panther)
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Old 06-22-2011, 07:45 PM   #3
Jackie07
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Re: Need some help...

Chelee,

It takes a while to see the result of a new drug (combo) Novelbine is originally invented for lung cancer. Perhaps the improvement you see right now is due to the late effect of the medicine. http://en.wikipedia.org/wiki/C45H54N4O8

Now the main focus needs to be back to the bone mets. I'll look it up and then post. Take care.
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Old 06-22-2011, 08:01 PM   #4
Rich66
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Re: Need some help...

If you need to switch and have to wing it with something low toxicity, could try Herceptin+Xeloda+Cytoxan+Tamoxifen or Faslodex+Zometa. Regular or metronomic dosing.
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Old 06-23-2011, 12:11 AM   #5
Chelee
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Re: Need some help...

Thanks Rich. That's more the idea I'm looking for until things improve some. I feel much better now, but sure hate the thought of starting up a new chemo/targeted therapy. I wish the FDA would approve T-DM1 so I could have that at a reduced dose...I'm sure that would give my bone mets a run for their money. After the Navelbine incident my CA27.29 did drop...but just got word they are rising again so I'd like to get started on something?

Jackie I'm sorry for the confusion. I was trying to save ppl from reading a novel and didn't make myself very clear. Navelbine works well for me, but my onc was suppose to start me off on a low dose. Instead she gave me a standard two wk dose of Navelbine, and far too much Herceptin which had very serious consequences for me. Any other idea's of drugs that might not affect my lungs as bad I would appreciate it. I realize there are no guarantees. But I have to do something soon.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 06-23-2011, 04:26 AM   #6
Ellie F
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Re: Need some help...

Happened to get an 'education' about xeloda yesterday by chance. It has a low toxicity profile and may be good for your lung issue.

Ellie
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Old 06-23-2011, 11:17 AM   #7
ElaineM
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Wink Re: Need some help...

I am sorry you are having a rough time.
Have you considered Tykerb with a chemo?
The reason I mentioned Tykerb is that the dose can be adjusted on a daily basis if you are having alot of problems.
If you can't take Navelbine and Herceptin maybe Abraxane (usually less side effects than Taxol) or Xeloda (a daily dose adjustment might be possible)would help?
Some of our members are taking Halaven which seems to be effective for them, but I don't know how that affects the lungs.
There is a drug that is being used by some bc patients called Metforam. I am not sure of the spelling, but it was developed for diabeties. I think recent testing showed promise for her2 positive estrogen positive breast cancer.
I wonder if some of the older chemos would work too?
I wonder if adding calcium, vitamin D and magnesium to the Zometa would help?
I am just throwing some things to think about out there.
In the meantim take good care of yourself. I have my fingers crossed for you too.
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Old 06-23-2011, 11:54 AM   #8
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Re: Need some help...

Dear Chelee -

Very sorry to hear that your lungs are not recovering faster from the Navelbine problem.

Have you considered seeing a radiation oncologist to discuss having those spots in your bones radiated? This would knock back the cancer and not expose you to hard chemos.

I am surprised if your regular doctor did not mention this possibility.
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MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
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Old 06-23-2011, 01:44 PM   #9
tricia keegan
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Re: Need some help...

Chelee I was wondering the same as Steph about the bone mets???

Sending good thoughts for you!
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Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
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Old 06-23-2011, 02:09 PM   #10
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Re: Need some help...

Chelee;
Wish I had some advice to offer you. Please know I am rooting and praying for you that you will find the right treatment.
Hugs,

Kris....
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06/08/09 - 55, IDC, IIIA, ER+/PR-/HER+++
Nottingham 6/9 - Grade 2 5.2cm, several nodes
06/23/09 - Neoadjuvant - TCH Herceptin til June
10/07/09 - Finished Chemo
10/27/09 - Mastectomy RB
Path Report: RB No residual tumor pCR,
2 of 15 pos - .5mm largest micromets
12/18/09 - Radiation started (28)
02/05/10 - Finished Radiation
01/11/10 - Started Femara
06/22/10 - Finished Herceptin.. My son's 22nd BD. Hope it's a sign! Hoping for the best.
11/15/10 - Started Walter Reed BC Vaccine trial at
1/04/11 - Sibley Mem. Had to withdraw due to met
01/23/11 - Stage IV - Brain Met 1.6cm 1.7cm
02/03/11 - Gamma Knife (2 fracts to minmize necrosis)
03/01/11 - Gamma Knife
6/11 - Necrosis
7/11 - Necrosis stopped & Tumor progression
8/11 = Now think it's really necrosis
9/11 - Avastin every two weeks -- It's working!! Necrosis is shrinking.
12/11 - Necrosis gone AVASTIN worked.
12/11 - Bone &CT found


Oct '10 - Ran Hartford 1/2 Marathon to Thank Dr. Slamon for Herceptin!
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Old 06-23-2011, 06:21 PM   #11
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Re: Need some help...

Chelee,

I have no further advise, but wanted to say that you are a wonderful inspiration to us all and that you simply must find a regime that gets you back to NED! I am so upset to hear you have been struggling so with your treatment. I know we can react to drugs strongly at times and dosing can be problematic for one and not another. Sending you love and prayers for something that is gentle for you and effective! Please keep us posted, Chelee. Love you.
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Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
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Old 06-24-2011, 02:36 AM   #12
Chelee
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Re: Need some help...

Today I had an appt. with a 2nd opinion onc about this problem. Which just shows more proof of what a well informed and educated bunch of people we have on this board. This onc said adding Xeloda to Herceptin would be a good choice without lung issues. It was also mentioned to add Tykerb/Xeloda both to Herceptin. Abraxane was another choice to consider. So Elaine and Ellie you guys get an A+. I also remember last yr I went out to see Dr. Mortimer at City of Hope & she suggested Xeloda since I was concerned about my lungs. Also mentioned was Herceptin/Faslodex since I am highly ER pos.

Steph my onc did mention radiation but she thought I was going to enroll into the T-DM1 trial so it was never brought up again? I've had rads to RT femur two yrs ago..not sure if I can hit it again or not? But my left femur and ilium hasn't had any rads. That's a question I will ask my Ortho onc at upcoming appt.? It would be nice if I could just hit those spots for now and avoid chemo as long as possible. (I've had one stubborn axilla node that Femara/Herceptin has taken care of thankfully.) Last CA27.29 was up to 45.1 which isn't terrible...but high for me. Want to bring that down quickly. Thanks so much to all of you! Some times I just feel so over whelmed when it comes to decisions like this? Can't thank you enough!

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 06-24-2011, 07:55 AM   #13
Rich66
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Re: Need some help...

So the (disturbing) Navelbine/Herceptin dosage blunder may account for the recent lung issue. But you also had lung damage from Taxotere during adjuvant, right? Just painting the bigger lung sensitivity picture. I know it's only one anecodotal, but..I do know of a patient in her 40's who had Abraxane weekly and had to eventually stop due to pleural effusions...although it did knock things back in her liver.
If it's all bone mets..if Zometa isn't doing it, maybe Denosumab(Prolia)?
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Old 06-24-2011, 08:50 AM   #14
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Re: Need some help...

Chelee. I am also upset you have to go through this lung problem. You had enough. I hope you will build your plan quickly with your oncs and get back on track to healing. Having to let go of your treatment because of bad side effects (from a mistake?) and not having yet defined a new one is a difficult period on top of the physical problems. But the "brains" here and your oncs seem to have several options to offer. I am sending hugs. Michka
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Old 06-24-2011, 11:49 AM   #15
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Re: Need some help...

Chelee,
Speedy recovery! Hugs,
Karen
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Thyroid Eye Disease. 2003. Decompression surgery in 2009; eyelid lowering surgery in 2010.
Diagnosed: June 2010, liver mets. ER-/PR+10%; HER2+++.
July 2010: Begin Taxol/Herceptin. Eliminate sugar from diet. No surgery or radiation.
January 2011: NED
April 2011: Progression in liver only. Other previous affected areas eradicated. Stop Taxol/Herceptin after 32 infusions.
May 2011: Brain MRI: clear.
May 2011: Begin Tykerb daily, Xeloda twice per day for one week on, one week off, and Herceptin.
November 2011: Progression in liver. All other tumors remain eradicated.
December 2011: BEGIN TRIAL #09-093 Taxol, MCC-DM1 (T-DM1), Perjeta.
Trial requires scans every six weeks, bloodwork and infusions weekly.
Brain MRI: clear.
January 2012: NED. Liver mets, good riddance!
March 2012: NED. Developed SMA (rare blood clot) in intestinal artery and loss of sight in right eye due to optical nerve neuropathy. Resolved when Taxol removed this month.
Continue Protocol of T-DM1 weekly and Perjeta every 3 weeks.
May 2012: NED.
June 2012: Brain MRI: clear.
June-December 2012: NED.
December 2012: TRIAL CONCLUDED; ENTER TRIAL EXTENSION #09-037. CT, Brain MRI, bone scan: clear. NED.
January-March 2013: NED.
June 2013: Brain MRI: clear. CEA upticking; CT shows new met on liver.
July 3, 2013: DISASTER STRIKES during liver ablation: sloppy surgeon cuts intercostal artery and I bleed out, lose 3.5 liters of blood, have major hemothorax, and collapsed lung requiring emergency resuscitative thoracotomy, lung surgery, rib rearrangement and cutting deep connective tissue, transfusion. Ablation incomplete. This life-saving procedure would end up causing me unforgiving pain with every movement I make, permanently, otherwise known as forever.
July 26, 2013: Try Navelbine/Herceptin. Body too weak after surgery and transfusion. Fever. CEA: Normal.
August 16, 2016: second dose Navelbine/Herceptin; CEA: Normal. Will skip doses. Watching and waiting.
September 2013: NED, Herceptin only. CEA: Normal. Started Arimidex.
October-November 2013: NED. Herceptin and Arimidex. CEA, CA125, 15-3: Normal.
December 2013: Something brewing. PET lights up on little spot on liver; CEA upward trend, just outside normal. PET and triphasic liver scan confirm Little Met. Restart Perjeta with Herceptin, stay on Arimidex. Genomic sequencing completed for future treatments, if necessary.
January 2014: Ablate Little Met on the 6th. Happy New Year.
March 2014: Brain MRI: clear. PET/CT reveal liver mets return; new lung mets. This is not funny.
March 2014: BEGIN TRIAL #10-005 A(11)-Temsirolimus plus Neratinib.
April 2014: Genomic testing indicated they could work, they did not. Very strange drug combo for me, felt weird.
April 2014: Started Navelbine and Herceptin. Needed something tried and true, but had significant progression.
June 2014: Doxil and Herceptin.
July 2014: Progression. Got nothing out of it. Brain: NED.
July 2014: Add integrative medical hematologist-oncologist to my team. Begin supplements. These are tumor-busting, immune system boosters. Add glutathione, lysine and taurine IV infusions every three weeks.
July 2014: Begin Gemzar, Herceptin & Perjeta. Happy.
August 2014: ECHO perfect.
January 2015: Begin weekly Vitamin D Analog infusions. 25 mcg. via port.
February 2015: CT: stable.
April 2015: Gem working, but not 100%. Looking into immunotherapy. Finally, treatments for the 21st century!
April 2015: Penn Medicine. Dendritic cell immunotherapy.
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Old 06-24-2011, 02:36 PM   #16
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Re: Need some help...

Oh, I was too late...but was also in the camp noticing you had not had tykerb/xeloda - and agree that this plus herceptin could be a really good option.

The radiation thought is an interesting one as well provided you are fairly sure you are dealing "only" with the couple of bone mets.

Good luck, Chelee - there are lots of options.
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 06-24-2011, 04:24 PM   #17
Ceesun
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Re: Need some help...

Chelee, Wondering about the herceptin-tykerb combo for you? Any thoughts? Ceesun
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Old 06-24-2011, 05:40 PM   #18
Joan M
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Re: Need some help...

Chelee,

I hope you'll be feeling better soon, and I'm glad that you're mostly off the oxygen.

Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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Old 06-25-2011, 06:05 AM   #19
Pam P
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Location: MN
Posts: 731
Re: Need some help...

Chelee - I am sorry to hear of everything you are dealing with - you've had too much going on. I sounds like adding xeloda might be the key for you. I'm praying which ever path you decide to take that it will be gentle on you and effective on those bone mets. May the lungs heal soon too. You are so strong -- keep going, keep having faith in your ability to get through this hurdle. Pam
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6/01 IBC er+ her2+stage IIIb; mastecomy
7/01 AC, taxol; radiation
2/02 tamoxifen
9/02 stage IV bone mets femara
1/03 taxotere/herceptin/aredia
6/03 herceptin, aredia & faslodex
1/04 navelbine, herceptin, aredia
2/05 herceptin/aredia
7/05 xeloda/herceptin/aredia
3/07 xeloda/tykerb/aredia
5/08 taxol/avastin/aredia
2/09 gemzar/herceptin/zometa
7/09 Taxol/Carbo/Herceptin, zometa
10/09 navelbine/herceptin & zometa
2/10 herceptin & tykerb & zometa
4/10 add xeloda &aromasin
10/10 dx with dermatomyiositis triggered by cancer
11/10 restart herceptin, tykerb, zometa
12/10 surgery-place rod in R femur to stabilize bone
1/11 radiation to R femur - 20 tx
2/11 2nd surgery - rod in Left femur
2/11 tx eribulen -- suspended dx brain mets
3/11 brain mets wbr 20 tx
4/11 halaven; discontine 8/11 not working
8/11 radiation to left femur 20 tx'
8-9/11 rad to lower spine
9/11 abraxane/herceptin/zometa
9/12 xeloda/herceptin/zometa
12/12 ablation of liver
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Old 06-25-2011, 11:36 AM   #20
Sheila
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Location: Morris, IL
Posts: 3,507
Re: Need some help...

Chelee
Another vote for the Tykerb/Xeloda with the Herceptin....another option might be metronomic chemo for a short time....I know you are on top of things, for yourself and many of us here....always keeping you in my thoughts and prayers!
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Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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