 |
04-02-2008, 11:57 AM
|
#1
|
|
Senior Member
Join Date: Sep 2005
Posts: 589
|
Side effects of T-Dm1
I apologize for the redundancy as I know everyone that's been involved in this trial has already mentioned flu like symptoms the first day and an easier time afterwards, but I have to ask again. Caryn just her first weekly infusion yesterday at about 1:00 and is still experiencing a tough headache and high level of achiness. None of the nurses could share anything with her so I just want to confirm when these effects began to lessen for each of you and that the subsequent treatments were much easier. I just want to make sure that I give her accurate information.
Thanks to all,
Eric
|
|
|
|
04-02-2008, 01:53 PM
|
#2
|
|
Senior Member
Join Date: Sep 2005
Location: Newton, MA
Posts: 951
|
Hi Eric,
I felt the same way. It should get better with each treatment.
Barbara
|
|
|
|
|
04-02-2008, 04:10 PM
|
#3
|
|
Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
|
Hi Eric,
First tx - fever/chills that night, flu like with fever declining over the next 2 days
2nd tx - low grade fever for 2 days, and a bit headachy
3rd tx - no fever, no headache
But on all 3 times, I have been very tired the night of the infusion.
Seems to be getting better.
Caryn is on the weekly infusion schedule, so may have lesser side effects - I'm on the 3 week dose.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
|
|
|
|
|
04-03-2008, 06:16 PM
|
#4
|
|
Senior Member
Join Date: Jun 2007
Posts: 34
|
Hi Eric, My first infusion I had flu like symptoms for 3 days, today was my second infusion and I asked them to cut the benyedril from my pre meds which they did and I have had absolutely no side effects from it at all. Hope this helps, mykentuckyhome
|
|
|
|
|
04-03-2008, 06:27 PM
|
#5
|
|
Senior Member
Join Date: Sep 2005
Posts: 589
|
Thank you all. Is everyone getting benadryl? Caryn didn't.
|
|
|
|
|
04-03-2008, 06:31 PM
|
#6
|
|
Senior Member
Join Date: Sep 2005
Location: Newton, MA
Posts: 951
|
Hi Eric,
I had no meds. I was treated today and am up late because I have so much school work to do tonight.
Best wishes,
Barbara H.
|
|
|
|
|
04-03-2008, 08:54 PM
|
#7
|
|
Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
|
Hi Eric,
I've had no premeds - although last infusion my nurse wanted to give me some benadryl and I refused. She fought back, I won. The duration and severity of my "flu like" symptoms has decreased with each infusion.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
|
|
|
|
|
04-04-2008, 02:26 PM
|
#8
|
|
Senior Member
Join Date: Nov 2007
Posts: 210
|
the benadryl is for the runny nose, and rash... it also can cause some drowsiness..
you can also use over the counter claritin and or zyrtec for symptoms withou the drowsiness...
the benadryl is not typically a problem.. be happy they offer it.. i would be more concerned if they denied it..
run to live..
|
|
|
|
Posting Rules
|
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
HTML code is Off
|
|
|
All times are GMT -7. The time now is 12:13 AM.
|
Linear Mode
