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Old 06-29-2011, 03:51 PM   #1
Myra Lynn
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Join Date: Jul 2009
Location: New York
Posts: 106
CA27.29 ups & downs

Hello to everyone,
I am wondering what you might think or know of this: I am having follow-up blood tests and physical exams every 3-4 months. For some unknown reason the CA27.29 numbers are going up and down on blood tests, above the normal range and then down again. The first time the number went up, it was immediately after completing Herceptin. The onc insisted on a PET/CT scan and it indicated a hot spot (he thinks due to radiation tx.), and nothing showed on the CT scan. This month the number is up again, so I am repeating the blood test next week. It is making me anxious, but I don't know if it's anything to worry about since there is no clear pattern or progression. Anyone have experience with this or any thoughts on the matter?
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 06-29-2011, 04:27 PM   #2
Becky
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Re: CA27.29 ups & downs

My CA 27/29 is all over the place. I just went to the onc on Monday and I am awaiting my result. The last one was 19 but it had been 8 before and 11, 22, 29, 16 - I know its different than you - always under the magical 38. Alot of things can affect the CA#. Even caffeine consumption.
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Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
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Old 06-30-2011, 05:53 AM   #3
Myra Lynn
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Re: CA27.29 ups & downs

Thanks for the feedback, Becky. All of my blood test numbers are all over the place too, above and below the norm, but this one , when it exceeds 38, is raising concern. I don't know if there is really a "magic number" that predicts metastasis. I doubt it or else we would all know a lot more a lot sooner. Just don't know what to think.
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-07-2011, 11:14 AM   #4
Myra Lynn
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Re: CA27.29 ups & downs

My CA27.29 numbers started inching up, right after finishing Herceptin. Had a PET scan in Oct. 2010, but nothing conclusive. The numbers continue to rise, so now I am scheduled this Sat. for a Head MRI and later a PET scan. Still can't believe it.

Tried editing my profile, but can't seem to save it. Can someone help?
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-07-2011, 01:49 PM   #5
Jackie07
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Re: CA27.29 ups & downs

Myra,

I hope the scan gives you good news.

As for the signature, try change it to smaller size of font before 'save'.
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Old 07-07-2011, 08:47 PM   #6
Myra Lynn
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Join Date: Jul 2009
Location: New York
Posts: 106
Re: CA27.29 ups & downs

Thanks for the help and the kind thoughts.
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-07-2011, 09:44 PM   #7
Pray
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Re: CA27.29 ups & downs

Hi Myra,

Good luck to you on your scans!

In your signature you say your middle finger hurts, why is that? Is it because of the famara?

Ishy
__________________
dx 11/12/09 IDCI
Stage 3a
ER 98% PR 80%
Her2 +3
4/12 nodes
6 rounds TCH
Herceptin 12 months 3weeks
Rad. 30 tx
Tamoxifin 6 months stopped
Arimedex stopped 9/12 (side effects)
Aromasin 10/12
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Old 07-08-2011, 05:53 AM   #8
Myra Lynn
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Location: New York
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Re: CA27.29 ups & downs

Thanks Ishy. I so appreciate the support. Yes, it was from femara. Very severe pain. Took a month off; switched to Arimidex. Still a little swollen, but tolerable.
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-11-2011, 06:01 PM   #9
sassy
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Re: CA27.29 ups & downs

Hey Myra,

Are you trying to change your profile(this info is not shown on screen) or trying to change your Signature (details that are listed below your name after posts)?

Let me know and maybe I can help.
__________________
Rhonda (Sassy)
dx age 45
DX 2/15/05 Stage IIb (at surgery)restaged IIIa
Left mast .9cm tumor 5 of 14 nodes
Triple Positive
4 DD A/C
12 Taxol/Herceptin
33Rads
Strange infect mast site one year aft surg, hosp 1 wk
Herceptin for total of 18 months
Lupron Monthly 4 yrs
Neurontin for aches, pains and hot flashes(It works!)
Ovaries removed 11/09 stop Lupron and Neurontin
Arimidex 6 yrs (tried Femara, no SE improvement)
Tried Exemestane-hips got so bad could hardly walk
Back to Arimidex for year seven
Zometa 2X Annual for 7years, Lasix
Stop Arimidex 5/13
Stop Zometa 7/13-Bi-lateral Stress Fractures in Femurs from Zometa
5/14 Start Tamoxifen
3/15 Stem cell transplant to stimulate femur bone growth/healing
5/15 Complete fracture of right femur/Titanium rods both femurs
9/16 Start Evista stopTamoxifen
3/17 Stop Evista--unwelcome side effects!
NED and no meds.......
14YEARS NED!
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Old 07-11-2011, 07:21 PM   #10
Myra Lynn
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Join Date: Jul 2009
Location: New York
Posts: 106
Re: CA27.29 ups & downs

Hi Sassy,
I'm trying to change my signature. I have lost the sense of where that is and how you do it.
Your help is very welcome.
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-11-2011, 07:44 PM   #11
Jean
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Re: CA27.29 ups & downs

Hi Myra,
As Becky shared the CA 27-29 can be diverse but it is wise
to do another blood test. So much can effect the numbers.
As far as the pain in your finger.

Have you tried or thought of taking a joint supplement such as Cosamin DS (can be purchased in CVS). I take one tablet in the morning and one at night. It is amazing and may just do the trick for that finger.

Sending you positive energy for the scans. Please let us know how it goes.

jean
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Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
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Old 07-12-2011, 01:03 PM   #12
KristinSchwick
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Re: CA27.29 ups & downs

My oncologist said that in the first month after starting my therapy- Xeloda and Tykerb, don't be surprised if the number jumps up alot. He said that if a bunch of cancer cells die simultaneously, the Ca2729 number would increase and then in the following month it will stabilize and start to fall. So I guess, the Ca2729 test can fluctuate based on growth/death rates of the cancer. Hope that helps.
__________________
[B]Kristin
Aug 2010: diagnosed stage 3b, 4 mo. after birth of son. 29 yrs old and breastfeeding, ER/PR-, Her-2+ started Neoadjuvant therapy: 4x FEC, 10x abraxane & Herceptin
Feb 2011: L mx with recon. Path. showed only DCIS but 4/10+ nodes.
March 2011: 6 wks rads.
Mother passed, lower back pain.
Late May 2011: Bone mets but organs clear; Tykerb, Xeloda, Xgeva. Stopped Herceptin. Implant infected: removed implant.
October 2011: Bone progression; Gemzar and Carboplatin & restarted Herceptin.
Jan 2012: Progression, re-classified as ER+; Tykerb, Herceptin, Zoladex & Femara. Anti-E is working!
May 2012: ovaries out, markers stable but elevated. Cont. Herceptin, Tykerb, Xgeva & Femara.
Dec 2012: aromasin
Jan 2013: faslodex, herceptin, tykerb
Jun: Kadcyla
Aug: Rads to hip, then Perjeta, Herceptin & Taxotere
Nov 2013: Perjeta, Herceptin, Halaven
Early 2014: Affinitor, Aromasin, Perjeta, Herceptin.
June 2014: Estradiol, Perjeta, Herceptin
Aug 14: Tamoxofin, H & P
http://kristin-notdying-blog.blogspot.com/
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Old 07-12-2011, 02:20 PM   #13
Myra Lynn
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Posts: 106
Re: CA27.29 ups & downs

Thanks everyone,
I don't know if it's exactly the same substance as Cosamin DS, but I also highly recommend glucosamine sulfate.
The MRI to my head came back negative. I asked for it because of the CA27.29 numbers and ongoing problems with vertigo. The PET/CT scan is Sat. All positive energy is most appreciated!
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-12-2011, 04:58 PM   #14
chrisy
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Re: CA27.29 ups & downs

Sending positive thoughts for the Pet/CT. Glad to hear there is nothing in your head
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
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Old 07-12-2011, 07:47 PM   #15
Myra Lynn
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Join Date: Jul 2009
Location: New York
Posts: 106
Re: CA27.29 ups & downs

You got that one right, Chrisy!
Thanks for the well-placed humor. And just to add to the fun, I am right in the middle of the prep for a colonoscopy. (Got any more bad jokes?)
I don't know how I would manage without all of you!!
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-18-2011, 06:59 AM   #16
Myra Lynn
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Join Date: Jul 2009
Location: New York
Posts: 106
Re: CA27.29 ups & downs

Good news! The PET scan was completely clear. Will take another blood test end of August and take it from there. I am so relieved and grateful to all of you for your support. I don't know what I would do without you.
__________________
Mammo 6/2/09
left breast biopsy 6/12/09
Bad news 6/18/09!
7/17/09 lumpectomy
Stage 1- 0.5 cm IDC , DCIS 25%
HER2 +++, ER+95%, PR+10%
8/09 Muga Scan 65
8/19/09 beg. TCH 1Xwk. 12 wks.
last chemo 11/26/09
IMRT - 33 txs. 1/12/10 to 3/11/10
Herceptin 1X week for 1 yr. Ends 8/10
Femara 3X wk. started 1/13/10-t
oo much pain in middle finger; switched to Arimidex 4/28/10 -permanently swollen, but no pain. Will continue for 5 yrs.
10/2/11 CT/PET scan due to elevated CA27.29 of 40.5.
Hot spot in irradiated area. Score goes down again to normal range. Subsequent blood tests go up and down until 2 tests in row at elevated levels of 42.5 & 45.7.
7/9/11 Intermittent vertigo. As a precaution contrast MRI to head. NED.
8/15/11 Erratic CA27.29 may be result of new auto immune disease, bullous pemphigoid (skin problem)
Off Arimidex for 6 wks. to see if trigger finger improves
Switched to Aromasin, 3X wk., but affected my liver.
On 2/23/12 taken off AI's.

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Old 07-18-2011, 07:10 AM   #17
Jackie07
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Re: CA27.29 ups & downs

Wonderful news! Thanks for sharing.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe
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