"HR2 stongly positive" ?

[Luck2U]

Is being HR2 "stronly positive" always a bad thing in the scheme of a grade 1 tumor? My wife has a recently diagnosed large breast tumor (5+ cm) that they are considering for chemo to shrink the tumor prior to removal. The PET scan does not show any node involvement (or any other metastatic disease), but I guess that might not mean a lot until they look under the hood (so to speak). She is also ER positive, which I understand is a good thing. Have many of you gone the shrinkage route with good results? If you've had bad results, I'd just as not hear from you (relax, I'm kidding). Any way, I've read and studied until my eyes are bleeding, but talking with those who are on the front line seems might help me be the most helpful to my wife. Does everyone get deatly sick with Chemo? Please share what you are comfortable sharing.