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10-02-2007, 08:16 PM
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#41
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Senior Member
Join Date: Sep 2005
Location: Riverside, CA
Posts: 484
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Woohoo!!! What great news! Nice when it turns out to be something benign and not cancer related.
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10-02-2007, 10:28 PM
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#42
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Senior Member
Join Date: Sep 2005
Posts: 232
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Great news!!!!! Celebrate!
Karen
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10-02-2007, 11:24 PM
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#43
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Senior Member
Join Date: Aug 2006
Location: So California
Posts: 223
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awesome news!
congratulations Becky!
I think the entire Her2 support group is celebrating with you!!!
__________________
Leslie's Sister (Lisa)
Diagnosed 5/17/06
Left breast Stage II
5 cm. Her2Neu+++, ER-, PR-
1 positive node out of six,
double mastectomy 6/9/06;
TCH started 7/12/06
last chemo 10/25/06
herceptin ended 6-11-07
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10-02-2007, 11:33 PM
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#44
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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Am on the road, and quite exhausted, but glad to hear your news
my first impression was that hormones other than estrogen can influence cysts and my second was that aromatase is only one of 3 enzymes responsible for turning androgen like substances into estrogen like substances
(the other two seem to be inhibited by tibolone, a drug used to treat menopausal symptoms in Europe, which is not available in the US)
A quick check of PUBMED affirmed my impression--here are a few of the abstracts listed:
1:
Burch JB, Walling M, Rush A, Hennesey M, Craven W, Finlayson C, Anderson BO, Cosma G, Wells RL.
Related Articles, Links
Melatonin and estrogen in breast cyst fluids.
Breast Cancer Res Treat. 2007 Jul;103(3):331-41. Epub 2006 Oct 24.
PMID: 17061046 [PubMed - indexed for MEDLINE]
2:
Stricker T, Navratil F, Forster I, Hurlimann R, Sennhauser FH.
Related Articles, Links
Nonpuerperal mastitis in adolescents.
J Pediatr. 2006 Feb;148(2):278-81.
PMID: 16492444 [PubMed - indexed for MEDLINE]
3:
Enriori PJ, Vazquez SM, Chiauzzi V, Perez C, Fischer CR, Gori JR, Etkin AE, Charreau E, Calandra RS, Luthy IA.
Related Articles, Links
Breast cyst fluids increase the proliferation of breast cell lines in correlation with their hormone and growth factor concentration.
Clin Endocrinol (Oxf). 2006 Jan;64(1):20-8.
PMID: 16402924 [PubMed - indexed for MEDLINE]
4:
Bellemare V, Faucher F, Breton R, Luu-The V.
Related Articles, Links
Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.
BMC Biochem. 2005 Jul 14;6:12.
PMID: 16018803 [PubMed - indexed for MEDLINE]
5:
Rahman N, Davenport M, Buchanan C.
Related Articles, Links
Galactocele in a male infant with congenital hypopituitarism.
J Pediatr Endocrinol Metab. 2004 Oct;17(10):1451-3.
PMID: 15526725 [PubMed - indexed for MEDLINE]
6:
Boccardo F, Lunardi GL, Petti AR, Rubagotti A.
Related Articles, Links
Enterolactone in breast cyst fluid: correlation with EGF and breast cancer risk.
Breast Cancer Res Treat. 2003 May;79(1):17-23.
PMID: 12779078 [PubMed - indexed for MEDLINE]
7:
Costarelli V, Sanders TA.
Related Articles, Links
Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer.
Eur J Clin Nutr. 2002 Sep;56(9):925-7.
PMID: 12209383 [PubMed - indexed for MEDLINE]
8:
Stanosz S, Blicharczyk-Zalewska B, Wilk G, Kubisa M.
Related Articles, Links
[Relationship between estrogen, progesterone, total testosterone, androstenedione, and epidural growth factor in blood and breast cyst fluid]
Ginekol Pol. 2002 Jun;73(6):523-8. Polish.
PMID: 12185717 [PubMed - indexed for MEDLINE]
9:
Maeda Y, Tanaka E, Fujiwara M, Watanabe R, Furusawa H, Matsu T, Nakahara H, Nanba K, Higashi S, Setoguchi T.
Related Articles, Links
Accumulation of 4- and 5-ene steroid sulfates in human breast cyst fluids.
J Steroid Biochem Mol Biol. 2002 Jul;81(3):249-53.
PMID: 12163136 [PubMed - indexed for MEDLINE]
10:
Maeda Y, Kamimura R, Higashi S, Namba K, Tanaka E, Iwamura T, Setoguchi T.
Related Articles, Links
A simple, accurate, and sensitive assay method of dehydroepiandrosterone sulfate: application for quantitative determination in human breast cyst and duct fluids.
Steroids. 2002 Apr;67(5):333-8.
PMID: 11958788 [PubMed - indexed for MEDLINE]
11:
Gizienski TA, Harvey JA, Sobel AH.
Related Articles, Links
Breast cyst recurrence after postaspiration injection of air.
Breast J. 2002 Jan-Feb;8(1):34-7.
PMID: 11856159 [PubMed - indexed for MEDLINE]
12:
Elsadig RE, Reimann K, Yip CH, Lai LC.
Related Articles, Links
Inhibition of oestrone sulphatase activity in the MDA-MB-231 breast cancer cell line by breast cyst fluid from Malaysian women.
Anticancer Res. 2001 Jul-Aug;21(4A):2693-6.
PMID: 11724341 [PubMed - indexed for MEDLINE]
13:
Ruibal A, Nunez MJ, Piqueras V, Rabadan F, Lapena G, Schneider J, Tejerina A.
Related Articles, Links
[Human gonadotrophic hormone (HCG) in benign breast cyst fluid. Association between type I and type II biological activities]
Rev Esp Med Nucl. 2001 Apr;20(2):156-8. Spanish. No abstract available.
PMID: 11333827 [PubMed - indexed for MEDLINE]
14:
Budai B, Szamel I, Sulyok Z, Nemet M, Bak M, Otto S, Reed MJ, Purohit A, Parish DC, Kralovanszky J.
Related Articles, Links
Characteristics of cystic breast disease with special regard to breast cancer development.
Anticancer Res. 2001 Jan-Feb;21(1B):749-52.
PMID: 11299838 [PubMed - indexed for MEDLINE]
15:
Budai B, Szamel I, Sulyok Z, Nemeth M, Bak M, Kralovanszky J, Otto S, Besznyak I, Purohit A, Parish DC, Reed MJ.
Related Articles, Links
Influence of hormonal status of patients with cystic disease on the composition of cyst fluid and breast cancer risk.
Anticancer Res. 2000 Sep-Oct;20(5C):3879-86.
PMID: 11268470 [PubMed - indexed for MEDLINE]
16:
Bicikova M, Szamel I, Hill M, Tallova J, Starka L.
Related Articles, Links
Allopregnanolone, pregnenolone sulfate, and epitestosterone in breast cyst fluid.
Steroids. 2001 Jan;66(1):55-7.
PMID: 11090659 [PubMed - indexed for MEDLINE]
17:
Raju U, Sepkovic DW, Miller WR, Dixon JM, Bradlow HL, Levitz M.
Related Articles, Links
Estrone and estradiol metabolism in vivo in human breast cysts.
Steroids. 2000 Dec;65(12):883-8.
PMID: 11077086 [PubMed - indexed for MEDLINE]
18:
Erbas H, Lai LC.
Related Articles, Links
Effect of transforming growth factor beta 2 on oestrogen metabolism in the MCF-7 breast cancer cell line.
J Clin Pathol. 2000 Apr;53(4):322-4.
PMID: 10823131 [PubMed - indexed for MEDLINE]
19:
Enriori PJ, Hirsig RJ, Vico CM, Etkin AE, Negri JC, Enriori CL.
Related Articles, Links
Effect of natural "micronized" progesterone on the chorionic gonadotropin concentrations in cyst fluids of women with gross cystic breast disease.
J Steroid Biochem Mol Biol. 2000 May;73(1-2):67-70.
PMID: 10822026 [PubMed - indexed for MEDLINE]
20:
^^^^^^
17 HSD is one of those two other enzymes, the other is a steroid sulfatase
Progesterone may be responsible for your cysts
I am hanging on on very few hours sleep...so sorry I didn't make more sense, or add more to the discussion
Will see when I next have a chance to pursue this further
Hope this helps!
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10-03-2007, 01:37 AM
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#45
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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Even when traveling, Lani keeps us informed and educated! Her work is never done! Awesome.
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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10-03-2007, 03:00 AM
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#46
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Senior Member
Join Date: Sep 2006
Location: Savannah, Georgia
Posts: 301
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Becky,
I am so happy for you. What terrific news, and what a relief!! I hope that your week finishes even better and with far less stress. YEA!!!!!!!!
Love, Kelly
__________________
dx'd 05/06, 37 years old
er/pr-, Her2+, grade 3
double mastectomy, immediate reconstruction- implants
Stage 2b, 2 tumors- 2.2 cm and 0.6 cm, 3/5 + nodes
all scans clear
genetic testing- negative
06/06 began dd A/C x 4, 12 weekly Taxols w/ Herceptin
30 rads
Herceptin weekly x 1 year
Herceptin completed 08/07
Port removed 12/26/07 MERRY CHRISTMAS!!!!!!
05/17/08 Two year anniversary NED
"We gain strength, courage, and confidence by each experience in which we really stop to look fear in the face... you must do the thing that you think you cannot do."
-Eleanor Roosevelt
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10-03-2007, 09:05 AM
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#47
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Becky,
What wonderful news! Just goes to reinforce how imortant it is to do self exams!
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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10-03-2007, 01:05 PM
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#48
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Senior Member
Join Date: Sep 2005
Location: Los Angeles
Posts: 430
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I could not check site yesterday ,so today I am so relieved to hear the news. I can see your smile from here.
XOXO
MCS maria
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10-03-2007, 01:53 PM
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#49
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Senior Member
Join Date: Apr 2006
Location: Wilmington, Del.
Posts: 1,126
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This is great news. Now have some fun.
__________________
MJO
IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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10-03-2007, 05:19 PM
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#50
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Senior Member
Join Date: Jan 2007
Posts: 144
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Hooray!!
Soo glad it is just a Cyst! Made my day.
Emelie
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10-03-2007, 09:07 PM
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#51
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Senior Member
Join Date: Dec 2006
Location: Oregon
Posts: 715
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Becky,
So happy for the good news.
Catherine
__________________
Catherine
Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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10-04-2007, 10:16 AM
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#52
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Senior Member
Join Date: Dec 2006
Posts: 136
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Very Relieved As Well Becky!!!
__________________
Debra
Diag. 11/05 at age 40 triple positive
3.8 cm tumor and 9 mm tumor
Stage IIb/SN positive(no other nodes)Grade 3
Bilat. mastect. 12/05 (Rt.prophylactic) followed with AC/taxol/Herceptin/tamoxifen then switched to arimidex after hysterectomy in 12/06. August 07 switched to Aromasin due to severe jt. pain from Arimidex. Nov. 2011 No more meds and NED!
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