HonCode

Go Back   HER2 Support Group Forums > Articles of Interest
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 02-11-2023, 09:37 PM   #1
Nguyen
Senior Member
 
Join Date: Nov 2005
Posts: 468
How I treat HER2-low advanced breast cancer

How I treat HER2-low advanced breast cancer

https://www.thebreastonline.com/acti...2823%2900005-X

A B S T R A C T
Introduction: Targeting low levels of human receptor epidermal growth factor 2 (HER2) expression has reshaped
the treatment paradigm for half of the patients with advanced breast cancer. HER2-low is currently defined as a
HER2 immunohistochemical expression of 1+ or 2+ without amplification by in-situ hybridization. Until
recently, HER2-targeted agents were ineffective in treating patients with HER2-low disease.

Areas covered: In this narrative review, we summarize the current management of HER2-low breast cancer. We
highlight the findings of the DESTINY-Breast 04 phase 3 trial, which confirmed the efficacy of trastuzumab-
deruxtecan (T-DXd) for the treatment of patients with advanced, pretreated HER2-low breast cancer. We also
discuss how to implement this new treatment option in treatment algorithms of hormone receptor (HR)-positive
and triple-negative tumors, as well as how to optimally manage selected toxicities of T-DXd.

Expert opinion: T-DXd is currently the standard of care for patients with advanced, pretreated, HER2-low breast
cancer. Based on the design of the DESTINY-Breast04 trial, the current optimal place in treatment algorithms is
after the first line of chemotherapy, both in HR-positive and triple-negative breast cancer. Up to 1015% of the
patients receiving T-DXd are expected to develop interstitial lung disease, which in 12% of the cases can be
fatal. Adequate monitoring and prompt management are required to minimize the impact of ILD and to safely
implement T-DXd in clinical practice.
Nguyen is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On

Forum Jump


All times are GMT -7. The time now is 07:53 PM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2023, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter