XBB1.5 The most infectious variant to date is becoming dominant in the US. Yet, it seems people are not taking covid seriously anymore. So we have to be even more on-guard. The Jama article below shows we need to be self-inform.
All of the currently (1/17/23) available antibody based regimens do not work against it.
I hope that you have received the bi-valent vaccine booster shot. Limited current data seems to indicates Moderna is better than Pfizer. Regardless, bi-valent booster shot from both Pfizer and Moderna work better as compared to previous booster against XBB1.5.
Note that screening checklist below includes drugs that interact with Paxlovid.
Nguyen
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Getting Treated (Paxlovid) for COVID-19 Shouldn’t Be This Difficult
https://jamanetwork.com/journals/jam...rticle/2800108
PAXLOVID Patient Eligibility Screening Checklist Tool for Prescribers
https://www.fda.gov/media/158165/download
COVID-19 Treatment Guidelines
https://www.covid19treatmentguidelin...gov/therapies/
The XBB1.5 COVID-19 variant: 7 questions, answered
https://www.mdanderson.org/cancerwis...159615489.html
"...5. Why should cancer patients and their caregivers pay particularly close attention to XBB1.5?
XBB1.5 is highly transmissible — and possibly the most transmissible subvariant so far, based on lab studies. That’s due to the specific mutations this one acquired, which make it much more contagious..."