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Old 11-13-2006, 04:53 PM   #1
al from Canada
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Dear Sally.

Navelbine with or without xeloda has been very successful with liver mets, with herceptin of course. Maintenance xeloda and herceptin also works well.
Good luck,
Al
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Old 11-13-2006, 05:00 PM   #2
jessica
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Ugh!I'm so sorry- Liver mets...I know/knew them well! I was dx'd w/liver mets @my primary dx in 2002. I was NED for a year on 2 occassions, but a single liver met kept recurring, so I finally had a liver resection last December, since I was NED every where else. So far so good...!

My very first combo was Navelbine+Herceptin, but I progressed on that combo, so we abandoned that & moved on to Taxol+Hercep/qweekly.
My disease was very sensitive to TH - "melting away" my disease as my onc says-from "innumerable, immeasureable lesions" to NED in 13 weeks. After one recurrence of the single met, just 4 weeks of TH srunk the met to undetectable by PET.
I did try ABRAXANE+Herceptin at one point, but it was ineffective-no response-so we moved on to Taxol+Carbo+Hercep. It did the trick, but was much harder for me than just TH.
In my case, I didn't progress while on chemo, but recurred in the absence of chemo. The Hepatectomy was our shot at a "cure" for the liver.

It is such hard decision to make, stick w/what you know was effective or switch treatment, & all the unknowns. We are all so different in how we respond to different combos. One person's magic bullet might be very different from someone else.

Hang in there. Keep us posted. And Keep the Faith~

ps-yet another option to consider: the EAP Tykerb+Capecitibine trial

Last edited by jessica; 11-13-2006 at 05:27 PM.. Reason: typos
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Old 11-13-2006, 06:05 PM   #3
Rupali
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You should take 1000mg Curcumin and an AYurvedic medicine called as Guggul. These have very beneficial effects for the liver.
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Old 11-14-2006, 07:39 AM   #4
Tessa
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Guggul

I believe that Guggul is also known as /is similar too Boswellia serrata, which has been discussed as an anti-inflammatory, and useful for liver mets, elsewhere on this site.
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Old 11-14-2006, 09:00 AM   #5
heblaj01
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Both Boswellia Serrata & Guggul have been found to interfere with the major CPY 3A4 enzyme (of the P450 family) which is necessary for the metabolism of several chemo drugs.
So taking one of these supplements concurrently with chemo may reduce the chemo effectiveness &/or increase its side effects.
This does not necessarely mean the supplements should be disregarded in all cases but it means care must be taken as to when & how to use them.

http://www.sciencenews.org/articles/20041002/food.asp
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation
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Old 11-14-2006, 09:09 AM   #6
Rupali
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You should take Guggul with Triphala or a combination of Guggul with some other recommended ayurvedic combinations.
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