its back

Laurel · 05-13-2021, 05:49 PM

Sorry to hear the beast is in your pelvis and lungs as well. So it is Her2 positive mets? Really sorry you are suffering and will pray you get some relief. Chemo is a tough go. No doubt about it. How long until your next scan?

donocco · 05-14-2021, 02:44 AM

Laurel

I noticed on your signature line you switched back to Tamoxifen.
If they are using antidepressants for hot flashes you have to be careful which
one they use. Tamoxifen is an inactive prodrug that is changed to an active form by means of the enzyme Cyp2D6. Antidepressants like Prozac / Paxil Wellbutrin or Celexa inhibit this enzyme and prevent the formation of the active drug. Effexor Celexa and Pristiq are much less inhibitory toward Cyp2D6'. I dont want to alarm you, just a heads up.

Paul