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06-04-2009, 07:42 AM
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#41
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Senior Member
Join Date: Nov 2005
Location: Colorado
Posts: 76
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aromasin
I switched from Tamoxifen to Aromasin about 2 years ago. The joint pain was very bad with Aromasin, so my doctor prescribed Celebrex. It makes a huge difference for me. I stopped the Celebrex a couple of months ago for a week to see what would happen. The pain was bad again. I still have joint pain while on Celebrex, but it is tolerable. I remain NED, but am high risk for a recurrence, so will continue the Aromasin.
Karen
__________________
Karen Raines Hunt
Dx April 2005 at age 46
stage 3A, very large (12cm) tumor
2 positive axillary lymph nodes
ER+/PR+, Her 2 +++
Bilateral mastectomy, radiation, reconstruction, A/C, Taxol, Herceptin, Tamoxifen, Aromasin
5 yrs since diagnosis and NED
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06-04-2009, 11:40 AM
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#42
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Senior Member
Join Date: May 2007
Location: DFW area (TX)
Posts: 431
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AI and autoimmune
I tried to click the link to the article concerning AI's and autoimmune association.
Please repost...the link didn't work.
THanks!
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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06-04-2009, 11:50 PM
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#43
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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I wonder if Fulvestrant has same side effects since it seems to work different from SERMs and AIs. My hunch is that based on recent studies showing it can synergize with chemos (search in Articles) it will keep moving up until it is an adjuvant tx.
Interestingly, I was just looking at some old visit notes where the previous onc couldn't see any possible connection between Arimidex and joint issues. A bit behind the curve as always..
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06-05-2009, 05:22 AM
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#44
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Terri,
The link to the abstract about autoimmune disease and AI arthralgia was from the 2008 ASCO. Apparently, they do not archive abstracts from prior meetings on their website once the current meeting abstracts are added to the site. If I can locate another source for it, I will link it for you, but at the moment I am not sure where else to look for it.
Hopeful
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06-05-2009, 06:33 AM
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#45
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Senior Member
Join Date: May 2007
Location: DFW area (TX)
Posts: 431
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article
Thanks Hopeful!
__________________
Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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06-05-2009, 06:28 PM
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#46
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Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
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I read somewhere that the aches and pains associated with both Tamoxifen and A.I.'s is lessened by taking large doses of Vit D. I take 2500 U daily with Calcium and I haven't had any serious stiffness with my Tamoxifen. I am hoping I will tolerate A.I.s as well when I switch over in another year.
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
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06-05-2009, 06:52 PM
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#47
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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1: Crit Rev Oncol Hematol. 2009 Apr 13. [Epub ahead of print] Links
Fulvestrant in the treatment of advanced breast cancer: A systematic review and meta-analysis of randomized controlled trials.
Valachis A, Mauri D, Polyzos NP, Mavroudis D, Georgoulias V, Casazza G.
Department of Medical Oncology, University General Hospital of Heraklion, Greece.
PURPOSE: To compare efficacy and tolerability of fulvestrant with aromatase inhibitors and tamoxifen that actually represent the standard of care in hormone-sensitive breast cancer. METHODS: Systematic review and meta-analysis of available trials. Primary outcomes were overall survival, time to progression, clinical outcome and objective response. Secondary outcome was the tolerability profile of the drugs. RESULTS: Four trials were identified with 2125 eligible patients. There was no statistically significant difference between fulvestrant and other hormonal agents in terms of overall survival (pooled HR: 1.047, 95% CI: 0.688-1.592), time to progression (pooled HR: 0.994, 95% CI: 0.691-1.431), clinical benefit (pooled OR: 1.044, 95% CI: 0.828-1.315) or objective response rate (pooled OR: 0.949, 95% CI: 0.736-1.224). A higher incidence of j oint disorders (pooled OR: 0.621, 95% CI: 0.424-0.909; P=0.014) was noted in patients receiving hormonal agents other than fulvestrant. CONCLUSION: Fulvestrant was similar to other hormonal agents with respect to efficacy measures, with good tolerability profile.
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