taxol/carbo/herceptin not working

[Pam P]

Just got home from the doctor. My PET/CT shows slight progression on bones since the last scan in July. This didn't worry the onc. too much as it appeared mild, but my ca2729 jumped another 350 points since a month ago. It's now up to 1358!!! It's almost tripled since July.

This has the onc concerned - and me very scared. He is taking me off the taxol/carbo & I start navelbine next week. I could have started today, but my platelets were only 89 so had to wait. I will continue with weekly herceptin & zometa every month.

I was on navelbine for 1 yr several years ago. I don't remember the s/e being too bad, it did knock down my wbc so had to do neupogen which I'll do again.

But I don't think from what I've read that when people go back on a previous chemo that it is very effective or for very long so I'm very nervous that the tide is turning for the cancer being under control. Just in 2009 taxol/avastin failed, gemzar failed, taxol carbo failed, now on to navelbine.

The research nurse is checking to see if there's a t-dm1 that I can get into now, but nothing has panned out yet for various criteria restrictions.

Has anyone done navelbine a 2nd time & had any luck? To me navelbine seems whimpy up against taxol/carbo.

I feel like I'm starting to go down a spiral with all these changes, more common low white, red & platelet blood counts. The good thing is I feel pretty good - grateful for that - but I can't even trust how my body feels to reassure me that it's staying strong.