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Old 04-23-2007, 08:57 PM   #1
atdec05
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IHC2 and FSH 8.3 (original tumor) - took Herceptin

IHC2 and FSH 9.1 (recurrence) - will take Herceptin

- Anna
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- Anna

Stage I - DX 9/2005 ER/PR-, HER2+, grade 3, DCIS, IDC multi-focal (1.05cm)
 DD 4 A/C finished Jan 31, 2006
Herceptin weekly finished Jan 31, 2007
recurrence to chest wall on last month of Herceptin
Stage 3B - 3/15/07 - 2 carcinomas in dermal lymphatic
Rads finished 6/5/07
12x TH finished 9/10/07
12/07 - Clear scan!
3/08 - 4 month Melatonin trial
1/09 - osteoperosis - start Alendronate
2/09 - 4-month Simivastin trial
3/13 - take drug holiday after 5 years of Alendronate
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Old 04-23-2007, 09:28 PM   #2
Lolly
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Hi Michele!
IHC 3+, FISH 4.9
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 04-23-2007, 09:33 PM   #3
Melissai
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Hi! My IHC was considered "borderline" 2+ and my FISH is 2.1 and I was given AC x4 and Taxotere x4 with weekly herceptin and now 9 more months of herceptin by itself. I too have been trying to find out what the prognosis differences are if you are a low level her2+ versus a higher number FISH score. If anyone out there knows any info on this I would really appreciate it. Thanks to all of you for all your knowledge. Melissa
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Old 03-09-2007, 07:57 PM   #4
harrie
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My numbers
I don't know what IHC is, but my FISH score for HER2 was 4.7 and I am currently undergoing herceptin, taxotere and carboplatin.
harrie
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Old 04-23-2007, 08:45 AM   #5
Hazel Joyce
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Hi, Michele.
My FISH results:
Amplified
Her-2/cen 17 ratio = 10.5
Average Her-2/neu copies per cell: 20.0
Average cen 17 copies per cell: 1.9
I don't see any IHC numbers on my path report.
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IDC Stage IIIA
Diagnosed Nov 2006 (routine mammogram), age 51
Lumpectomy, lymph node dissection Dec 2006
3 cm tumor, 8 cancerous lymph nodes
Grade 3, ER/PR -, HER-2/neu +++ (by FISH, average 20 copies per cell)
A/C x 4, Taxol x 12, Herceptin x 47 weeks
35 radiation treatments
Completed treatment on April 3, 2008
Chest port removed October 2009
11 years since diagnosis NED
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