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Old 02-09-2013, 10:31 AM   #21
karen z
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Re: must read article --should her2+ breast cancer be divided into ER+ vs ER- subtype

Hopeful you are definitely right- very popular right now !
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Old 02-09-2013, 10:32 AM   #22
karen z
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Re: must read article --should her2+ breast cancer be divided into ER+ vs ER- subtype

Many of you might be interested in a new thread I started that is highly relevant to all of us Estrogen positive gals. It is called:

From Dr. Neil Love: Thoughts on ATLAS and more
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Old 02-09-2013, 05:09 PM   #23
europa
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Re: must read article --should her2+ breast cancer be divided into ER+ vs ER- subtype

I am trying to get my Oncologist to approve two tests. The first to test if I metabolize Tamoxifen. My feeling is, I am ER+ but very weakly. So if I don't metabolize the drug at all, what's the point of taking it. Then I wanted her to test my hormone levels. Well, she said if I can produce data that Tamoxifen can fuel HER2+ cells, she would sign off on it. But to her knowledge, that has not been explored in any trials whatsoever. Does anyone know of anything that even suggests this? I've been looking online and have Found nothing.
__________________
DX 10/2011
PET Scan + MRI 10/2011
Lumpectomy 11/11/11
Stage 2B +++ ER+(10%), PR+(5%), HER2+++(1 positive node, 1 micromets to second node)
AC started 12/2011 ended 1/2012
Taxol + Herceptin weekly for 12 weeks ended 4/2012
30 zaps of radiation done 6/2012
Tamoxifen 6/2012
every 3 weeks of Herceptin for another year.
Metformin Trial 8/12
10/12 MRI- CLEAR
01/13 BRAIN MRI- CLEAR!
01/13 Neck MRI- CLEAR!
FINISHED HERCEPTIN 1/9/2013...Woot Woot
Starting Walter Reed Vaccine Trial 2/13
CT Scans + ultrasound of abdomen CLEAR-5/13
02/2015 through 11/2015 emergency D&Cs for Tamoxifen induced uterine polyps which caused uncontrollable hemorrhaging
12/2015 blood clot to left leg caused by Tamoxifen. No longer taking it. On Xarelto, a blood thinner
12/2015 Ablation to prevent hemorrhaging from potential issues with Tamoxifen residue in my system
1/2016 continuing journey without hormonal therapy. Reevaluating the option of a hysterectomy and oopherectomy.
4/1/2018 2mm stroke. Yes, stroke! No cause ever found but they believe it was a migraine that went bonkers and created a tiny clot. No deficits. I was back to normal with 24hrs. Now on baby aspirin for life.
7/27/2018 hysterectomy and oopherectomy
01/07/2019 Mastectomy and expanders put in
3/22/2019 Vtach, almost died. Cause unknown.
7/22/2019 New perky boobs put in
7/21/2020 Off of all drugs but a baby aspirin because of the stroke in 2018.


www.mychemobag.org
www.facebook.com/mychemobag

8 YEARS NED
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Old 02-09-2013, 09:17 PM   #24
CarolineC
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Re: must read article --should her2+ breast cancer be divided into ER+ vs ER- subtype

Hi Europa,

If you do a search on this website for Tamoxifen and Her2, you will find many threads that are useful; this is where I found alot of my information. I hope these links work-the following are just a few of some very informational threads-we are so lucky to have such brilliant people on this site!-and the one from breastcancer.org is quite helpful as well-especially posts by orange1.

http://her2support.org/vbulletin/showthread.php?t=44143
http://community.breastcancer.org/fo...1#post_1555269
http://her2support.org/vbulletin/sho...tamoxifen+her2
http://her2support.org/vbulletin/sho...tamoxifen+her2

Caroline
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Dx Age 47 July/09 Stage 2B/3
Left Mast. Aug 09- 1 of 3 positive nodes in axillary dissection (yes only 3)
ER+ 90%, PR+ 20%, HER2+++
4 x AC, 4 x Paclitaxol and H (Neupogen for 7 cycles), Herceptin complete Nov 10
Mar–Apr 2010 25 Rads
Apr 10-Oct 11- Tamoxifen
Oct 11 – 3 cm met to sternum
Oct 11-Letrozole for 3 mths, start Clasteon-bone remodeller
Nov-Dec 11 - Happy 50th Birthday -20 rads to sternum
Jan-April 2012 Taxotere/Herceptin-6 cycles (Neupogen for 5)
Herceptin every 3 weeks-Letrozole added Nov 2012
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Old 02-11-2013, 09:58 AM   #25
AlaskaAngel
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Question Re: must read article --should her2+ breast cancer be divided into ER+ vs ER- subtype

What a mine field to try to cross!

I continue to wonder why there doesn't seem to have been any studies done solely on those who have been NED from the beginning with long-term survival, to see what could be gleaned from that.

Analyzing the cancers is one goal, but since there is such a failure to separate out other variables in addition (such as whether treatment included steroids, or included bone builders, or included blood boosters), it wouldn't surprise me if studies end up with researchers reaching the wrong conclusions.

No one has been able to explain with accuracy to me why there are those of us HER2+, HR+ with tumors over 1 cm who refused blood boosters, never received trastuzumab, and for me at least, never took an AI, and only took tamoxifen for 1 3/4 years, yet have no recurrence after over 10 years.

Could they learn something by creating a study based on us?

A.A.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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