Re: TDM-1 news
Lorraines plats were checked 2 days before each 3 week tx. If they werent up enough, she delayed another 1-3 weeks, which is the limit in the old exp. access protocol. ( 6 weeks total ) Gen clinical team gave her even more extra time after sepsis ( saved her life probably ). And shes cruising on 3.0 every 3 weeks. plats 70,000-80,000 +. She gets a platelet rash , which is achain of red spots on neck, and red bumps on wrist. She also gets little red bumps in various places like FOB describes. Plats that rebound above 100,000 is great in our opinion, we hope L. gets back there someday.
But for all tdm-1'ers , plats need to be watched ., at least 30% have that issue , dropping below 100,000 ( i think maybe even more than 30 % ). below 100, 000 they have to be watched if they dont rebound before next dose . If they didnt rebound over 75,000, that meant another reduction , to 3.0, if they continued to drop, to 2.4 ( which L. narrowly avoided ) below that - you're Dropped from tx !! So, read up on protocol , ask questions !
In L's old protocol , , like many trials , once you go down in dose you cant go back up. Until approval, when we can be done w/ This FDA . Oh, how I want to be done w/ This FDA for ever ! meaning get rid of Pazdur and his tdm-1 " advisors ".
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