Mechanism discovered:how inhibition of fatty acid synthetase causes apoptosisofbccell

[R.B.]

Herceptin is reported to downregulate FAS

Tamoxifen impacts on FAS.

The synergy of certain fats with certain chemo may suggest some chemo may impact on FAS.

Trials looking at gene expression show that different omega three six ratios alter a wider range of gene expression.

My guess - Factors such as availability of particular types of fats, and now those fats impact on eicosandoid pathways, interaction with oestrogen pathways, up down regulating PPARs, MMPs, endothial pathways create the likelyhood of a veritable Pandora's box of options of the result of invertention in FAS.

RB