COVID-19 Severity and Waning Immunity After up to 4 mRNA Vaccine Doses in 73 608 Patients With Cancer and 621 475 Matched Controls in SingaporeA Nationwide Cohort Study
https://jamanetwork.com/journals/jam...rticle/2807035
Key Points
Question How effective is COVID-19 vaccination in patients with cancer in protecting against severe disease and does protection wane over time?
Findings In this nationwide cohort study including 73 608 patients with cancer and 621 475 matched controls, third and fourth vaccine doses were associated with incremental protection in both groups. No significant decrease in protection against severe disease was observed 5 months after the third and fourth vaccine dose.
Meaning Each booster COVID-19 vaccine dose was associated with significant clinical protection in patients with cancer, lasting at least 5 months in actively treated patients with cancer and cancer survivors, underscoring the benefit of boosters.
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