Go Back   HER2 Support Group Forums > Articles of Interest
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Thread Tools Display Modes
Old 09-21-2020, 01:54 PM   #1
Senior Member
Join Date: Nov 2005
Posts: 530
First New Drug in Years Reduces Recurrence in High-risk Hormone Receptor Positive Ear

I usually post only Her2Positive and late Met articles. But I was caught by the phrase “…first time in 20 years…” in the articles below so here we are. By the way, my wife Her2+++ is taking Abemaciclib at a lower dose.

Definition of “high risk” early stage ER+ Her2- bc: “…High risk was defined as patients with four or more positive pathologic axillary lymph nodes or one to three positive axillary lymph nodes and at least one of the following: tumor size ≥ 5 cm, histologic grade 3, or centrally assessed Ki-67 ≥ 20%...”

Ki-67 protein (nuclear proliferation marker): < 10% low, 10-20% < moderate ; > 20% high; higher percentage = faster proliferation. Unfortunately (or fortunately) as are the cases of ER/PR receptors (12-15% discordance) and Her2 (6-8%) it is possible to have discordance between primary site and metastatic site.

The easy to read version.


The detail version.


Attached Images
File Type: jpg nucleargradeXsmall.jpg (185.4 KB, 483 views)
Nguyen is offline   Reply With Quote

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On

Forum Jump

All times are GMT -7. The time now is 06:02 AM.

Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter