Cannabinoid receptors – main ligands are Omega 3 and 6 derivatives, not hemp products

[R.B.]

Are CBD products bio-active in PGE2 and other pathways - yes https://www.google.com/search?client...b-d&q=CBD+PGE2

Might that have pharmacological potential in particular circumstances - yes

Are Omega 6 and 3 and downstream product pathways including COX and LOX products central in tissue creation and repair including in pregnancy - yes

Do we know what effect CBD cannabinoids are having in pregnancy and early development - no



Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

http://www.scielo.br/scielo.php?scri...62008000300015

"In the last 45 years it has been possible to demonstrate that CBD has a wide range of pharmacological effects, many of which being of great therapeutic interest, but still waiting to be confirmed by clinical trials. It is important to highlight that many effects of CBD draw a bell-shaped dose-response curve, suggesting that the dose is a pivotal factor in CBD research. The wide range of CBD effects can be explained by the multiple mechanisms through which CBD acts, although further research is needed to clarify the precise mechanisms that underlie some of the potentially beneficial effects of CBD."

[R.B.]

Endocannabinoid Signaling in Female Reproduction


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382454/

"Since then, numerous studies have been published on cannabinoid signaling in female reproductive events, including preimplantation embryo development, oviductal embryo transport, embryo implantation, placentation, and parturition."

"almost all pregnancy events are regulated by endocannabinoid signaling, and in most cases, optimal outcomes can only be achieved under normal physiological endocannabinoid levels. Either silenced or enhanced endocannabinoid signaling derails these processes. This is a trait of endocannabinoid signaling that provides a route for medical manipulation in each pregnancy event. However, the in-depth mechanism by which endocannabinoid signaling exerts its role is still not clear. In addition, it would be interesting to study the mechanism behind how lower and higher cannabinoid signaling generates similar phenotypes. Further studies on endocannabinoid signaling with respect to female reproduction will generate new molecular mechanisms governing pregnancy events."