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Old 02-02-2019, 09:19 PM   #1
Becky
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Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
Re: Treatment after Kadcyla?

Prior to using herceptin, adriamycin and drugs similar to it were the gold standard for her2 positive bc. This is because it it very effective if you are also topo2 positive which about half the people who are her2 are. This is because the topo2 Gene lies very close to the her2 Gene and both get messed up and mutated. However, with herceptin, this didn't matter anymore so they moved away from those drugs. So, of they aren't going to be giving you herceptin, then this isn't a bad choice.
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Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 02-03-2019, 06:14 AM   #2
Juls
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Join Date: Mar 2014
Location: UK
Posts: 563
Re: Treatment after Kadcyla?

Hi Becky,

Thanks for your reply. Will look into all this later today.
Apparently there is a similar drug to Kadcyla (mono clonal ?) which was mentioned last week. Think Keytruda so will also look at that. It does look as if I'll have to start one of the old ones!
Told on 31st I had a few weeks to make a decision, now have to decide by next Thurs 7th - Due to platelets being low(?) First thing I note is Co-Codomal lowers platelets!
Thanks again
Juls
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