Treatment after Kadcyla?

[donocco]

Jules

Epirubicin for all intents and purposes is a form of Adriamycin.It is an Anthracycline chemical and has the same side effects as Adriamycin such as hair loss, mouth sores, low white cell counts and possible cardiac damage. The dosage of Epirubicin is different than Adriamycin (say 100mg /m2 vs 50mg /m2 but I would consider Epirubicin to Adriamcin the same way as I would see Ativan to Xanax. Eprubicin as far as I kn ow has no anti-Her 2 Neu effect, it will reduce tumour burden.

Paul

[Becky]

Prior to using herceptin, adriamycin and drugs similar to it were the gold standard for her2 positive bc. This is because it it very effective if you are also topo2 positive which about half the people who are her2 are. This is because the topo2 Gene lies very close to the her2 Gene and both get messed up and mutated. However, with herceptin, this didn't matter anymore so they moved away from those drugs. So, of they aren't going to be giving you herceptin, then this isn't a bad choice.

[Juls]

Hi Becky,

Thanks for your reply. Will look into all this later today.
Apparently there is a similar drug to Kadcyla (mono clonal ?) which was mentioned last week. Think Keytruda so will also look at that. It does look as if I'll have to start one of the old ones!
Told on 31st I had a few weeks to make a decision, now have to decide by next Thurs 7th - Due to platelets being low(?) First thing I note is Co-Codomal lowers platelets!
Thanks again
Juls

[Juls]

Hi Paul,
Thank for your reply. I really don't know which way to go. Each time I speak to My Oncologist something else is mentioned. Then I'm left to research myself! I guess I have to reduced the tumour burden first. Although to date I don't know how many etc. Liver is the issue.
I have had 1 liver met on and off for 6 years & then I have a successful ablation on it but other liver mets appear within weeks!
Juls