What’s the next step once Perjeta/Herceptin and T-DM1 stop working?

[margo]

I have been on Kadcyla (T-DM1) since February 3, 2016. It is beginning to fail. Is anyone enrolled in any of the Abemaciclib (LY2835219) trials?

http://www.lillyoncologypipeline.com/cancer-type/breast-cancer

"Significance

Despite successful HER2-directed therapies, many patients with HER2-positive breast cancer will succumb to their disease once tumor cells develop resistance. Here, we show that the cyclin D1-CDK4 pathway can mediate this resistance, and that targeting resistant tumor cells with a CDK4/6 inhibitor resensitizes them to anti-HER2 therapy by increasing their dependence on EGFR family kinase signaling. Concomitant HER2 and CDK4/6 inhibition synergistically inhibits cell proliferation,
controls tumor growth in vivo, and delays tumor recurrence in a transgenic mouse model. These effects are associated with a reduction in the phosphorylation of both Rb and S6RP, two important mediators of the G1/S transition. Our results have led to the development of a randomized clinical trial for patients with metastatic HER2-positive breast cancer."