Hi my partner Catherine has had skin mets that have come and gone over the years. She has recently had a recurrence after 3 years break despite being on Kadcyla in that time. We were referred to a skin specialist/plastic surgeon who is going to do a procedure called electrochemotherapy in 3 weeks time.
The Doctor seemed confident that he could help so we have our fingers crossed.
Please see link below as this may help with your wife's situation if you can access it.
I wish you and your wife all the best.
https://en.wikipedia.org/wiki/Electrochemotherapy
Steve