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11-17-2013, 01:37 AM
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#161
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Senior Member
Join Date: May 2006
Location: Mesa, Az
Posts: 219
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Hi to all off my IT friends, have been doing IT herceptin at 100mg weekly for almost 6 weeks. Still on Tykerb 750 daily as tolerated. IV 105mg Herceptin weekly. Tried a short run of Navelbine, with a negative bone marrow I still have a left shift, (some type of funky immature cells) in the cbc every week. Changes in CBC started with navelbine so that was a short run of that for me. Will redo scans here the next few weeks looking to go to every two weeks by summer if all scans are good. I am able to obtain my Herceptin thru the the mail in pharmacy thru my husbands insurance plan.
Peace and prayers and healing to all
Darita
__________________
dx 1/06 IDC 2cm 38 at dx
2/06 L mast nodes 3/9+ SNB neg ER-/Pr - her2 + Stg 4 liver/pelvis
3/06-9/06Taxol/Carbo/zometa/Herceptin
3/07 6 brain mets WBR down to c-2
4/07 osteonecrosis jaw
1/08 mri new 9mm lesion right lower side
2/08 gamma knife 1 lesion 11/08 regamma
10/09 latent rad necrosis to brain met,
1/20/10 crani: lesion necrosis w active cells continue her add tykerb
1/11 NED just Ingrown toenail! YEAH GOD
8/11 Tykerb, herceptin weekly, elevated her2 levels, negative scans
oct -march 11 new neuro deficits lower legs
3/12 2 spinal metsTykerb, Herceptin
04/12 4050cGY rads T 2-4 & T7-9
5/12 Brain,cervical lumbar clear/thoracic slight decrease
10/12 t 2-4 shrunk t-9 grew start Xeloda, 02/13 stop xeloda,5/13 on metformin, decadron, Tykerb, iv and IT herceptin 5/30/13 total #11 #2 of 80mg dose weekly.
9/13 100mg of IT her, IV hern, 750 mg tykerb, 3mg dec.
last Mri T--3 SHRUNK t7-9 shrunk no edema. Left shift in CBC bone marrow BX negative.
10/13 Ct has shown Double left ureters with stones/cysts in them, after 3 births and lots and U/S iit takes cancer to figure out you have 2 smaller ureters going into 1 kidney!
12/13 Mri brain no new lesions, cervical and lumbar arthritis.
Tspine lesion at T3 stable, T 7-9 GROWTH lots of pain
1/29/14 HIHO HIHO its off to Neuro surgery I go
Life is Good when you wake up in the morning and take a breath and know that God has given me another day.
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01-23-2014, 06:29 AM
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#162
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Senior Member
Join Date: May 2012
Posts: 105
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
MRI of this week:
Carol is still NED even now that she is no longer doing IT herceptin for last 8 months.
Seems that damage done with the stroke has opened the BBB for IV herceptin to pass through. She is only taking 6mg per kilo IV herceptin and nothing else. No signs of fits for the past 7 months.
Stroke is clearing but still some old hemorrhage can be seen in it.
She still has quite a good quality of life, but still exercising to start walking again.
Mario
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01-23-2014, 10:13 AM
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#163
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Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Mario,
Good to hear Carol is doing well. Nina is afraid to stop the IT or IV Herceptin. She is at IV Herceptin every three weeks and IT Herceptin every four weeks. The IV is administered locally and the IT is administered at MD Anderson in Houston.
I think you have a good point about the BBB. It is likely that the IT Herceptin did the job in the time it was administered. The stroke occurring may have been due to the removal of the cancer cells and the collapse of the support system in the brain. That was something I would not have considered a potential issue, but I will forward to others about deep brain lesion potential side effects. The problem is that if the you do not stop the cancer lesions from growing they will kill the person as well. That is something that will have to be thought about by the Brain Cancer specialists.
Good luck. I would love to get out to see you, but it probably will not be this year. I will be going to Hawaii in July for Nina and my birthdays, and then business travel in the Us otherwise.
Glad to hear that Carol is recovering from the stroke. Our thoughts are with you and we hope that your lives are able to return to close to normal.
Paul and Nina
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01-24-2014, 01:03 AM
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#164
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Senior Member
Join Date: Sep 2007
Posts: 118
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
So glad to hear that Carol is still doing well and gaining strength.
Susan is still getting IT Herceptin 80 weekly. She is now on Abraxine also weekly IV for the enlarged clavicle lymph nodes. The Abraxine is shrinking them and she is doing well on this routine. They did have to cancel one treatment of the Abraxine because of low platelets, but other than losing her hair, she is handling it well and feeling fine.
She has not had an MRI for a while but she is sure feeling much better.
My best to all,
Ev
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01-24-2014, 11:50 PM
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#165
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Senior Member
Join Date: May 2006
Location: Mesa, Az
Posts: 219
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Hi Mario I am glad Carol is doing better. Evilin I am glad daughter feeling better as well. Thanks Paulfor leading the way.
I am having surgery to debulk and remove the t 8 lesion and fluid on the 29th. Neuro symptoms are rapidly getting worse. with no quick IT drug available this is what My family and medical team have decided to do. Cool thing is it will be done in Phoenix at Barrows Neurological institute, world class neuro drs and some really good technology and inpatient neuro rehab. since I am already his patient was able to get in very quick. The fluid has pushed the lesion more toward the right side laminectomy style. Best case coming out weak, which I already am, but should stop the growth and stop further nerve damage. Then go back to IT/IV herceptin
Peace and Prayers to all
I will update when they let me have my electronics back!!!!!
__________________
dx 1/06 IDC 2cm 38 at dx
2/06 L mast nodes 3/9+ SNB neg ER-/Pr - her2 + Stg 4 liver/pelvis
3/06-9/06Taxol/Carbo/zometa/Herceptin
3/07 6 brain mets WBR down to c-2
4/07 osteonecrosis jaw
1/08 mri new 9mm lesion right lower side
2/08 gamma knife 1 lesion 11/08 regamma
10/09 latent rad necrosis to brain met,
1/20/10 crani: lesion necrosis w active cells continue her add tykerb
1/11 NED just Ingrown toenail! YEAH GOD
8/11 Tykerb, herceptin weekly, elevated her2 levels, negative scans
oct -march 11 new neuro deficits lower legs
3/12 2 spinal metsTykerb, Herceptin
04/12 4050cGY rads T 2-4 & T7-9
5/12 Brain,cervical lumbar clear/thoracic slight decrease
10/12 t 2-4 shrunk t-9 grew start Xeloda, 02/13 stop xeloda,5/13 on metformin, decadron, Tykerb, iv and IT herceptin 5/30/13 total #11 #2 of 80mg dose weekly.
9/13 100mg of IT her, IV hern, 750 mg tykerb, 3mg dec.
last Mri T--3 SHRUNK t7-9 shrunk no edema. Left shift in CBC bone marrow BX negative.
10/13 Ct has shown Double left ureters with stones/cysts in them, after 3 births and lots and U/S iit takes cancer to figure out you have 2 smaller ureters going into 1 kidney!
12/13 Mri brain no new lesions, cervical and lumbar arthritis.
Tspine lesion at T3 stable, T 7-9 GROWTH lots of pain
1/29/14 HIHO HIHO its off to Neuro surgery I go
Life is Good when you wake up in the morning and take a breath and know that God has given me another day.
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01-25-2014, 09:20 AM
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#166
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Senior Member
Join Date: Sep 2007
Posts: 118
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
I will be thinking of you on the 29th and am hoping you have great success with the surgery. Will be looking forward to your update.
My very best wishes !
Ev
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05-15-2014, 11:38 AM
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#167
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Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
IT Perjeta is still not in clinical trials. Nina is doing well, but has a spot near where they did the excision and Gamma knife in November 2009. In March 2014, it was a dire issue. In April it was maybe an issue. Last week it was probably not an issue. Stressed out for 60 days needlessly. Back to MRI scans once every two months on the brain and spine. So far so good. I looked at the MRI scans from the past four and a half years (wow...that seems short some days and such a long period other days). I saw slight differences over the past year (one little part looks more nodular), but it might be death of cells (like radiation oncology thinks) versus cells regrowing.
Cigna was being a pain but it was because of a new person approving the reviews. Now that is settled. Still, $4500 deductible before out of pocket max met (did that by February 15). Put $2500 into FSA, but other $2,000 comes out of my wallet immediately.
The Perjeta in the brain using Intrathecal means is still not approved. Genentech will not say why. I hope there were some changes that were to be done in terms of dosing to get to 100 mg per dose. We shall see.
It is strange to be working at the plant that is saving so many lives. I spread the word from this blog on the people that are being treated: The mothers that see their children get married, get to see an extra year of sports, that get to hold their grandchildren, that get to take another trip with their significant others, and that just get to see additional summers. I also talk about the side effects of drugs, the desperation of not having good answers, and reading about the more negative outcomes.
This disease is one I would not wish on any person. We are at the forefront of treating it. There are so many new methods coming down the line that the disease is likely to be put into remission on a regular basis in ten years. Much like patients that were fighting infections in the early 1940s as antibiotic manufacturing start, the women that are undergoing treatment in many cases just need a few more years to get great treatment options. I hope that I can shorten the time for new drugs to market, can inform those with issues of options to get additional quality time, and to be part of the strong emotions that this group gives out.
Keep supporting one another, and I will do the same. Traveling 80% of the time since Jan 13, four weeks home M-F but home every Friday night while leaving every Monday morning, is hard. The benefit is that I should be able to review and respond to emails better.
Fight back. Do not give up hope. Ask questions. Get Answers. The impossible happens because medical care people stay inside the box, some doctors think outside the box, but stand on top of the box and use it to get better and be heard.
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05-15-2014, 01:18 PM
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#168
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Senior Member
Join Date: Jul 2008
Posts: 186
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
ASCO abstract re: T-DM1
"Author(s): Rupert Bartsch, Anna Sophie Berghoff, Margareta Rudas, Elisabeth Bergen, Michael Gnant, Karin Dieckmann, Katja Pinker, Christoph Zielinski, Guenther G. Steger, Matthias Preusser; Department of Medicine I, Clinical Division of Oncology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Institute of Neurology, Medical University of Vienna, Vienna, Austria; Institute of Pathology, Medical University of Vienna, Vienna, Austria; Medical University of Vienna, Vienna, Austria; Comprehensive Cancer Center, Department of Surgery, Medical University of Vienna, Vienna, Austria; Department for Radiation Therapy and Radiation Biology, Medical University of Vienna, Vienna, Austria; Department of Radiology, Medical University of Vienna, Vienna, Austria; Medical University of Vienna, and Initiative “Leben mit Krebs, Vienna, Austria, Vienna, Austria; Department of Medicine I, Clinical Division of Medical Oncology, Medical University of Vienna, Vienna, Austria
Abstract Disclosures
Abstract:
Background: Local treatment options such as radiotherapy or neurosurgery are the mainstay of BM management. Whole brain radiotherapy (WBRT), however, is associated with severe late-toxicity. The LANDSCAPE trial established lapatinib plus capecitabine (LapCap) as primary systemic treatment in oligosymptomatic patients (pts) with multiple Her2-positive BM. Limited evidence exists regarding the activity of antibodies in BM. T-DM1 is an antibody-drug conjugate linking trastuzumab (T) to an anti-microtubule agent. T-DM1 provides activity in pts progressing upon T and has lower toxicity as compared to LapCap. Here, we investigated the activity of T-DM1 in newly diagnosed or progressive BM. Methods: A total of six consecutive pts (median age 55 years) with Her2-positive breast cancer and BM were treated with T-DM1. In two asymptomatic pts, T-DM1 was administered as primary systemic therapy, while four subjects had already received local therapy and had documented CNS progression. T-DM1 was administered intravenously at a dose of 3.6 mg/kg body weight every three weeks; re-assessment of disease status was performed every three cycles. At baseline and restaging, MRI was performed. CNS response was defined as a reduction of lesion size of ≥50%. Results: Median follow-up was 6 months (m) and median brain metastases-free survival 11 m, respectively. All pts had received prior T, three (50%) had already received LapCap, and two (33.3%) pertuzumab. Currently, 4/6 pts (1 with primary treatment and 3 receiving T-DM1 upon CNS progression) are assessable for CNS response. 2/4 pts (50%) had partial remission, while one patient progressing upon prior local therapy had stable disease lasting for 15 cycles. One patient had minor response on MRI but no reduction of pre-existing brain oedema and increasing cortisol doses and was therefore deemed PD. A significant LVEF drop was observed in one heavily pretreated patient. Conclusions: This prospective case series again indicates that systemic therapy offers activity in Her2-positive BM. Currently, LapCap remains the standard of care. Still, T-DM1 offers relevant clinical activity; therefore, the role of T-DM1 in BM should be investigated in larger studies."
http://abstracts.asco.org/144/AbstView_144_134326.html
You're a real trooper Rolepaul.
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05-15-2014, 01:37 PM
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#169
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Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Pretty interesting as TDM-1 has a molecule that might allow blood brain barrier penetration. It is not good for direct input into the cavity (though an Ommaya reservoir or lumbar puncture) but IV appears to have some benefit. The goal right now is to get IT Herceptin and Perjeta going in clinical trials.
We are on the edge of making this disease go into remission for many women. I just want to say that many of us in the industry want this to occur as soon as possible.
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07-02-2014, 08:25 AM
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#170
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Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
After 30 months, there is some signs of one very small spot on the brain slightly increasing in size when compared versus one year ago. Looking at Perjeta via Intrathecal to address the spot after this long with Herceptin. As far as is known, this would be the first time ever done. If there are not good results, then the spot will get Gamma Knife treatment in November. Otherwise, Nina walks five miles a day, does Water Aerobics, Yoga, drives to the airport, and is generally good shape. Keeping at the cutting edge in the fight against the monster.
30 months after getting a three to six month probable lifespan and still doing the Energizer Bunny routine.
I hate to lose. Never give up.
Paul
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07-02-2014, 09:49 AM
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#171
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
That one little spot hopefully it's just scar tissue. Thanks for the update Paul! Nina's story gives me so much inspiration! From 3 months to 30 months that's a miracle with much love and blessings!
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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08-29-2014, 10:18 AM
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#172
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Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
So the good news is that Nina's brain lesion is now called stable. They see incredibly small changes in the MRI scans of her one brain lesion. The docs do not know what it means. The thought is stay the course with IT Herceptin every 4 weeks and another set of MRI scans in 8 weeks. No IT Perjeta because they want to have the IT Herceptin study at Northwestern fully enrolled first. Kind of angry, but I understand.
Spot found on lymph node at top of lung, so told Perjeta/TDM-1/Taxotere. Went with TDM-1 only for now. Nina is going to Italy for 17 days this Saturday so did not want any side effects to slow her down. Another CT scan in eight weeks, next time at MD Anderson, to determine the treatment plan for that one.
Made at people dumping ice water and then donating for research on ALS. How about putting money into the cost of treatment, particularly the difference between the $4500 for max out of pocket and the $2500 for FSA to pay for treatments. Many of the people in the US have a $2000 surprise in February, March, or April as they find out that there is a gap.
Both Nina and I are staying strong. Had 55th birthdays, 19th anniversary, and got our 29 year old son married. None of these would have happened without hard work and a lot of faith from this site. Keep on giving one another a shoulder to lean on.
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08-29-2014, 05:14 PM
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#173
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Senior Member
Join Date: Sep 2007
Posts: 118
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Paul,
Best wishes to you and Nina. Susan is still doing the ommaya Herceptin every week. Just finished cyber knife to an enlarged subclavicle lymph node.
Her genome results indicate afatinib or neratinb is appropriate for her because of the mutations found. They are trying for the afatinib first but on first try the insurance has refused approval.
The chemotherapy is getting tough for her - low blood counts and unsteadiness. She has taken herself off of them - hoping for the more targeted approach.
Ev
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09-05-2014, 01:36 PM
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#174
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Senior Member
Join Date: May 2012
Posts: 105
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Carol still doing fine. She started to walk again this summer. She has been off IT herceptin for last 16 months now. Last MRI and CT scan done in May showed she is still NED and stroke clearing more and more. Quality of life getting better day by day. Will scan brain again next week. She is only taking 6mg/kilo IV herceptin and nothing else. Been taking this only treatment for past 16 months now. She has lost 35 kilos in 16 months. Now standing at 77 kg.
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09-06-2014, 10:14 AM
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#175
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Senior Member
Join Date: Jun 2012
Posts: 81
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
Hello everyone!
I am late to this party,
Just found this thread today, 9-6-14.
I was initially diagnosed April, 2012...had R mastectomy May, 2012....A/C chemo July, 2012, followed by Taxol/Herceptin, then Herceptin only until Sept 2013.
Discovered one 2 cm brain lesion in June 2014, following a seizure. No other symptoms. Did one Gamma knife treatment at Cleveland Clinic....follow up MRI showed 50% reduction of lesion, no necrosis, no new lesions. Finished steroids in late July, currently considered "stable" , no symptoms, and scans show no evidence of disease elsewhere in body.
My question is: should I be doing more treatment? (ie IT Herceptin, etc.)
All of my docs are saying "It's all good, could be isolated incident, scans every two months, treat as needed."
I felt ok with that, but now, after reading thru this thread, I am questioning our decision. My quality of life is pretty much normal...I am working, exercising, participating in life as usual, feeling healthy and fine.
Really disliking HER2+ and all of the "grey areas" !!!
Very appreciative of all of the love and support on this board!!! Thankyou!!
__________________
Dx 4-12-2012
R unilat Mx 5-25-2012 (no reconstruction)
Stage 2B, Grade 3, Her2+++, Er + (15%), Pr -
4.2 cm, 2/14 nodes +
3 AC, 4 T/H
Zoladex 4 months
Oophorectomy Feb 2013
AI daily
Herceptin every 3 wks until Sept 2013
Gamma Knife June 2014, 2 cm brain met
Liver mets Oct 2014
Taxotere/herceptin/perjeta-CLEOPATRA trial Nov 2014-Mar 2015
"RISK BEING SEEN, IN ALL OF YOUR GLORY!" Jim Carrey
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09-08-2014, 03:09 AM
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#176
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Senior Member
Join Date: May 2012
Posts: 105
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
If you are her2+ and herceptin is working in all your body except your brain, you may decide to get herceptin to your brain by intrathecal ways. But I am no expert in this. Maybe rolepaul can help you better at this.
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10-22-2014, 03:31 PM
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#177
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Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
We are back and happy. Nina had a subcarinal lymph node that had doubled in size by August. The brain lesion was slowly increasing in size for five years. In August we switched to systemic TDM-1 and continued the IT Herceptin with Topotecan. It appears we have put Nina into full remission. That is beyond anything we could have hoped for. Nina is the only alive of 288 patients with brain/spine HER+ involvement at MD Anderson in the period of 2008 to 2012. As far as we know, she is the only one without whole brain radiation where the disease has been put into remission in the United States. There is hope for success in this area and for a standardized treatment that actually works.
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10-23-2014, 06:20 AM
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#178
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Senior Member
Join Date: Jul 2008
Posts: 186
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
To you, your wife, and the medical team THANK YOU for how well you've handled this crisis and the progress thus realized. What an inspiration!
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12-01-2014, 02:33 PM
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#179
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Junior Member
Join Date: Dec 2014
Posts: 1
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
hello read over the thread quite an inspration I am on the IT study in NewYork MY doc said in last visit That I have slight progression better then when we started in 1/14. Thought the thing to do i find a doc that would do the treetment off study at a higher dose. I did vary well at the start at twice then once a week treetments. Any thoughts where I may find some one????? east coast wold be great///////
thnks ahead of time
zue
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12-02-2014, 08:40 PM
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#180
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Senior Member
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 391
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Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
I think the IT Herceptin needs to be at least 1. mg per kg to work. Nina's was piggybacked with Topotecan, which may be important (but probably is not). Try Sloan Kettering in New York or ask at MD Anderson in Orlando (Dr. Nick in the Breast Center). Rumor has it that Genentech is looking at IT Perjeta out of Univ of South Calif, but I would not wait. Send me a personal email if you want.
Back for more MRI scans on Dec 13 through 15. Our son's 30th b-day is the 13th. We will celebrate the following weekend if things are good.
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