Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

[Rolepaul]

Mario,
Good to hear Carol is doing well. Nina is afraid to stop the IT or IV Herceptin. She is at IV Herceptin every three weeks and IT Herceptin every four weeks. The IV is administered locally and the IT is administered at MD Anderson in Houston.
I think you have a good point about the BBB. It is likely that the IT Herceptin did the job in the time it was administered. The stroke occurring may have been due to the removal of the cancer cells and the collapse of the support system in the brain. That was something I would not have considered a potential issue, but I will forward to others about deep brain lesion potential side effects. The problem is that if the you do not stop the cancer lesions from growing they will kill the person as well. That is something that will have to be thought about by the Brain Cancer specialists.
Good luck. I would love to get out to see you, but it probably will not be this year. I will be going to Hawaii in July for Nina and my birthdays, and then business travel in the Us otherwise.
Glad to hear that Carol is recovering from the stroke. Our thoughts are with you and we hope that your lives are able to return to close to normal.
Paul and Nina