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Old 09-07-2012, 09:03 PM   #1
Mandamoo
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Join Date: Jul 2011
Location: Melbourne, Australia
Posts: 432
Re: Thanks Mandamoo!

Ahh Italy - we had such a wonderful and warm (hot) time!
Capri was my favourite place - swimming through the grottos was a spectacular experience - maybe even spiritual - the true awesomeness of Nature! So much history, culture in this wonderful country.
Alas, back to dreary grey Melbourne but at least my cherry plum is blossoming to welcome us home.
I'm all signed up for Teresa - baseline scans next Wednesday and Friday and the treatment as soon as randomised hopefully early the following week. Looking at just doing Tykerb and Herceptin if I draw control (this will depend on how stable things have been in the 6 weeks since scans showed progression - I continued Tykerb while away and had a perception before I left but am now on nothing).
If things are rapidly happening we will do Abraxane and Herceptin.
I am OK with either arm with of course a preference to give TDM1 a go - all patients in the centre (5) are currently randomised to TDM1 - 1 stable and the other 4 with more impressive results.
How quickly Italy can be forgotten.
Finally added the pic from my 40th - it was a blast!
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Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis

June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions

Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
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Old 09-07-2012, 09:51 PM   #2
dawny
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Join Date: Oct 2011
Location: Geelong, Australia
Posts: 250
Smile Re: Thanks Mandamoo!

Hi Amanda
Thanks for the photo update, looks like you had a lot of fun!
Fingers crossed that you get TDM1. How long before you will know if you have got it? And how do you know, do they tell you straight off, or is it a guessing game?
Best of luck, keep thinking of Italy and smiling!
Dawn xx
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Dx May 27 2011, age 43
Stage 1V 3.6cm breast lump, spot on lungs, nodes chest + neck
HER2+ ER/PR-
Abraxane weekly - 16 weeks
Herceptin every third week
September 26 2011 N.E.D!
Herceptin ongoing
8th Dec 2011 Brain MRI - clear
20th Dec 2011 bone/cat scan clear still NED
April 2012 scans show axillary node lump - ? what to do...
June 2012 Axillary node dissection 1/11 nodes affected, a wide local excision shows DCIS. Now what to do again? Watch and scan 3 monthly
April 2013, two spots in nodes to chest wall, start TDM1 (Kadcycla) as part of clinical trial
July 2013 stable
Oct 2013 progression off TDM-1 (Kadcycla)
Nov 2013 radiation to lymph nodes in sternum
Dec 2013. Mastectomy right side, pathology shows tumour was HER-2 negative, no wonder TDM-1 (Kadcycla) didn’t work!
April 2014 NED. On Herceptin only
August 2014 NED. On Herceptin only
March 2015. NED. On Herceptin only
September 2015 NED on Herceptin only
March 2016. Pulmonary embolism, Clexane injections daily forever. Still NED On Herceptin only
Nov 2016. Bone Mets in ribs - Radiation. Don’t know if bone Mets are er-/pr-/HER2+ or triple negative.
Can’t give self injections on to tablets (Xarelto) for blood clots.
2017 NED - On Herceptin only
2018 NED - On Herceptin only
2019 NED - On Herceptin only
2020 NED - On Herceptin only
2021 NED - On Herceptin only
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Old 09-08-2012, 04:43 AM   #3
chrislmelb
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Location: melbourne, australia
Posts: 267
Re: Thanks Mandamoo!

I think you meant Herceptin, not perception!! Auto text lol.
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Christine

DX Sept 03 age 40 Stage 2B Grade 3 mastectomy (after 2 prior breast conserving surgeries)
"at least" 2.3 cm 3/12 nodes ER+/PR+ Her2+++
8 FEC. Tamoxifen then Arimidex. Ovaries out.
"late" Herceptin for 2 years (18months after chemo) on HERA trial. finished Herceptin Nov 2007.
Multiple bone mets May 2012 and now liver August 2012.
Abraxne, Herceptin and Zometa.
June 2013 Tykerb, Xeloda and Xgeva
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