Intrathecal Herceptin/Topotecan for Leptomeningeal Disease

[Rolepaul]

To all, there is hope with brain mets. Nina's MRIs show only normal background in the brain and spine. The PET scan came back as normal. The tumor markers are down to the normal population. There are no abnormal cells seen in the Lumbar Puncture or a vein draw. Treatment is going to nce every two weeks for the Intrathecal (and we hope the IV). TDM-1 works, but only if there is not Central Nervous System involvement. This approach will be investigated for those individuals with brain and spine mets from Herceptin based disease. We cannot thank the doctors at MD Anderson enough.