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Old 03-27-2012, 09:27 AM   #1
Hopeful
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Re: trends that weight management is going to be important in treating HER2-positive

AlaskaAngel,

I would just like to add that some of the steriods that are given as supportive drugs to chemotherapy also affect the metabolism by causing insulin resistance that can lead to diabetes, but, at the least, causes additional weight management issues for patients. This is a "hidden" risk factor that the medical establishment is also not addressing with patients entering treatment. It may also explain why metformin is being tested as a cancer treatment support drug that has the potential to reduce recurrence - it is addressing the steroid induced insulin resistance patients experience as a result of treatment.

Hopeful
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Old 03-27-2012, 09:54 AM   #2
AlaskaAngel
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Location: Alaska
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Metformin

Hopeful,

Thanks for those reminders about steroids and about metformin! I'm also hoping that metformin is helpful in actually causing stem cell death, which chemotherapy doesn't seem to provide.

A.A.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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Old 03-27-2012, 02:05 PM   #3
AlaskaAngel
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Join Date: Sep 2005
Location: Alaska
Posts: 2,018
A little hope....

... and a little chocolate, goes a long way....

http://www.nydailynews.com/life-styl...sEnabled=false
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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