Re: new targets being discovered for inflammatory bc
this article discusses techniques used to prove the necessity for certain genes/proteins/receptors to maintain growth and invasion of IBC
It also discusses which work in concert, which work as competitors
among the targets (the more specific the target, the less side-effects) are:
EGFR (FDA has already approved drugs)
Amphiregulin (a ligand rather than a receptor), aka AREG
DKK1
RHOB
networks associated with cell motility such as integrin-linked kinase signaling, and focal adhesion kinase signaling.
Wnt signalling
Notch signalling-- there are already trials of a gamma-secretase inhibitor in bc
Hope this helps!
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