Diet mechanism

[TanyaRD]

The results of this study are interesting. It is a large study with nearly 5000 women. The results represent a stark contrast to those from the WINS trial which found a reduction in dietary fat (especially saturated with an emphasis on monounsaturated fats in diet) reduced recurrence of breast cancer significantly, especially for triple neg breast ca. Of course, one thought with WINS is that weight loss/control from following a low fat diet may have been part of the reason for the risk reduction. The weight gain finding does not surprise me as it is fairly well established that increased fat=increased estrogen. It would be interesting to know what the guidelines for their "low carbohydrate diet" were and it lean proteins were encouraged or if low carb was also high saturated fat. At any rate, it looks like the message remains to be maintain or achieve a healthy weight, fat in moderation (avoiding saturated fat) and exercise.