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Old 06-04-2009, 11:44 AM   #1
TSund
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Location: DFW area (TX)
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Oye. Ruth's hair is very thin and she is currently on Tamoxifen. Is it possible this is an ongoing result of the TCH more than any particular ER+ drug?
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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Old 06-04-2009, 07:25 PM   #2
Becky
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Location: Stockton, NJ
Posts: 4,179
Terri

I believe that even in Ruth's case, it is lack of estrogen. Did Ruth experience Chemopause and are her periods back and normal? Tamoxifen can also block estrogen from getting to other estrogen receptors that need estrogen.
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Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 06-05-2009, 06:42 AM   #3
TSund
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Location: DFW area (TX)
Posts: 431
Tamoxifen and hair thinning

Ruth did experience chemopause and her periods are not back, but her ER markers at last check were still high enough that Dr. O. did not want to give her the AI.

What you say makes sense Becky. I suppose if it can pull estrogen away from the breasts it certainly could pull it from other places. I don't understand this drug; Tamoxifen can give extra estrogen to the uterus (bad) and bones (good) , if I understand correctly?

The hair thinning drives her nuts. She had gorgeous perfect hair before dx. If this ends up being the worst of it we'll be lucky tho.

TRS

P.S. What haircut do those of you with severe thinning use?
__________________
Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
TSund is offline   Reply With Quote
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